Longitudinal Single Cell Atlas of COVID-19 Identifies an Early, Transient Prognostic Signature

Dr Shvetha Sankaran
shvetha_sankaran@gis.a-star.edu.sg

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Dataset ID	Description	Technology	Samples
EGAD00001007995	COVID-19 scRNA-seq, TCR-seq and BCR-seq for 291 samples collected from 109 patients. Among 291 samples, 249 of them have two libraries (sequencing runs) for each assay, while 42 have only one library.	Illumina NovaSeq 6000	37
EGAD50000000345	Type 1 diabetes mellitus (T1DM) is a prototypic endocrine autoimmune disease resulting from an immune-mediated destruction of pancreatic insulin-secreting beta-cells. A comprehensive immune cell phenotype evaluation in T1DM has not been performed thus far at the single. In this cross-sectional analysis, we generated a single-cell transcriptomic dataset of peripheral blood mononuclear cells (PBMCs) from 46 manifest T1DM (Stage 3) cases and 31 matched controls.Our study reveals a surprisingly strong systemic dimension at the level of immune cell network in T1DM, defines disease-relevant molecular subtypes and has the potential to guide non-invasive test development and patient stratification.	Illumina HiSeq 4000 unspecified	22