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Characterization of mutational signatures in human cancer cell lines reveals episodic APOBEC mutagenesis

Multiple signatures of somatic mutations have been identified in human cancer genomes. To investigate whether mutational signatures continue to be generated, and if so their temporal patterns of activity, subsets of cell lines were cultured in vitro for extended periods and subjected to single cell cloning and whole genome or exome sequencing or directly to single cell whole genome sequencing. As expected, signatures of past exogenous exposures, such as tobacco smoke and ultraviolet light, were not generated in vitro. In contrast, signatures of normal and defective DNA repair and replication continued to be generated at essentially constant mutation rates. Signatures of APOBEC cytidine deaminase DNA-editing activity exhibited a distinctive pattern with substantial fluctuations in mutation rate over time and episodic bursts of mutations. The initiating factors for these bursts are unclear although retrotransposon mobilisation may play a role. This cell line set now constitutes a comprehensive resource of live experimental models of mutational processes of both known and unknown aetiologies potentially retaining the patterns of activity and regulatory influences operative in human cells in vivo.

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Studies are experimental investigations of a particular phenomenon, e.g., case-control studies on a particular trait or cancer research projects reporting matching cancer normal genomes from patients.

Study ID Study Title Study Type
EGAS00001002364 Cancer Genomics

This table displays only public information pertaining to the files in the dataset. If you wish to access this dataset, please submit a request. If you already have access to these data files, please consult the download documentation.

ID File Type Size Located in
EGAF00002048118 cram 522.1 MB
EGAF00002048119 cram 535.7 MB
EGAF00002048120 cram 588.8 MB
EGAF00002048121 cram 542.0 MB
EGAF00002048122 cram 613.3 MB
EGAF00002048123 cram 592.6 MB
EGAF00002048124 cram 684.8 MB
EGAF00002048125 cram 666.0 MB
EGAF00002048126 cram 605.7 MB
EGAF00002048127 cram 584.2 MB
EGAF00002048128 cram 626.9 MB
EGAF00002048129 cram 597.3 MB
EGAF00002048130 cram 600.3 MB
EGAF00002048131 cram 511.8 MB
EGAF00002048132 cram 639.6 MB
EGAF00002048133 cram 303.0 MB
EGAF00002048134 cram 261.2 MB
EGAF00002048135 cram 288.4 MB
EGAF00002048136 cram 355.9 MB
EGAF00002048137 cram 423.4 MB
EGAF00002048138 cram 336.2 MB
EGAF00002048139 cram 198.7 MB
EGAF00002048140 cram 374.3 MB
EGAF00002048141 cram 265.8 MB
EGAF00002048142 cram 390.5 MB
EGAF00002048143 cram 366.0 MB
EGAF00002048144 cram 536.6 MB
EGAF00002048145 cram 546.9 MB
EGAF00002048146 cram 605.7 MB
EGAF00002048176 cram 559.3 MB
EGAF00002048177 cram 606.4 MB
EGAF00002048178 cram 605.8 MB
EGAF00002048179 cram 711.3 MB
EGAF00002048180 cram 688.4 MB
EGAF00002048181 cram 629.2 MB
EGAF00002048182 cram 614.3 MB
EGAF00002048183 cram 644.0 MB
EGAF00002048184 cram 611.6 MB
EGAF00002048185 cram 616.8 MB
EGAF00002048186 cram 526.6 MB
EGAF00002048187 cram 665.1 MB
EGAF00002048188 cram 310.2 MB
EGAF00002048189 cram 268.0 MB
EGAF00002048190 cram 299.5 MB
EGAF00002048191 cram 364.7 MB
EGAF00002048192 cram 444.5 MB
EGAF00002048193 cram 345.3 MB
EGAF00002048194 cram 205.5 MB
EGAF00002048195 cram 383.7 MB
EGAF00002048196 cram 279.0 MB
EGAF00002048197 cram 401.0 MB
EGAF00002048198 cram 375.0 MB
EGAF00002048199 cram 509.9 MB
EGAF00002048200 cram 510.3 MB
EGAF00002048201 cram 558.5 MB
EGAF00002048202 cram 508.4 MB
EGAF00002048203 cram 568.2 MB
EGAF00002048204 cram 554.3 MB
EGAF00002048234 cram 639.1 MB
EGAF00002048235 cram 619.8 MB
EGAF00002048236 cram 579.7 MB
EGAF00002048237 cram 553.6 MB
EGAF00002048238 cram 590.1 MB
EGAF00002048239 cram 565.8 MB
EGAF00002048240 cram 573.3 MB
EGAF00002048241 cram 484.0 MB
EGAF00002048242 cram 590.5 MB
EGAF00002048243 cram 284.8 MB
EGAF00002048244 cram 244.2 MB
EGAF00002048245 cram 267.7 MB
EGAF00002048246 cram 334.6 MB
EGAF00002048247 cram 401.3 MB
EGAF00002048248 cram 314.8 MB
EGAF00002048249 cram 187.3 MB
EGAF00002048250 cram 353.0 MB
EGAF00002048251 cram 249.6 MB
EGAF00002048252 cram 365.8 MB
EGAF00002048253 cram 353.3 MB
EGAF00002048254 cram 512.0 MB
EGAF00002048255 cram 522.2 MB
EGAF00002048256 cram 576.0 MB
EGAF00002048257 cram 525.4 MB
EGAF00002048258 cram 581.6 MB
EGAF00002048259 cram 578.7 MB
EGAF00002048260 cram 679.3 MB
EGAF00002048261 cram 630.4 MB
EGAF00002048262 cram 596.3 MB
EGAF00002048292 cram 582.5 MB
EGAF00002048293 cram 614.8 MB
EGAF00002048294 cram 582.4 MB
EGAF00002048295 cram 586.7 MB
EGAF00002048296 cram 499.7 MB
EGAF00002048297 cram 620.7 MB
EGAF00002048298 cram 293.8 MB
EGAF00002048299 cram 253.2 MB
EGAF00002048300 cram 283.8 MB
EGAF00002048301 cram 345.3 MB
EGAF00002048302 cram 411.0 MB
EGAF00002048303 cram 325.6 MB
EGAF00002048304 cram 194.0 MB
EGAF00002048305 cram 364.5 MB
EGAF00002048306 cram 257.7 MB
EGAF00002048307 cram 386.5 MB
EGAF00002048308 cram 357.1 MB
EGAF00002048309 cram 541.0 MB
EGAF00002048310 cram 538.3 MB
EGAF00002048311 cram 594.2 MB
EGAF00002048312 cram 546.1 MB
EGAF00002048313 cram 592.9 MB
EGAF00002048314 cram 591.0 MB
EGAF00002048315 cram 693.0 MB
EGAF00002048316 cram 665.5 MB
EGAF00002048317 cram 611.9 MB
EGAF00002048318 cram 599.2 MB
EGAF00002048319 cram 632.2 MB
EGAF00002048320 cram 611.6 MB
EGAF00002048341 cram 607.4 MB
EGAF00002048342 cram 516.2 MB
EGAF00002048343 cram 646.2 MB
EGAF00002048344 cram 304.2 MB
EGAF00002048345 cram 262.5 MB
EGAF00002048346 cram 293.7 MB
EGAF00002048347 cram 358.5 MB
EGAF00002048348 cram 426.0 MB
EGAF00002048349 cram 338.5 MB
EGAF00002048350 cram 199.8 MB
EGAF00002048351 cram 376.8 MB
EGAF00002048352 cram 267.1 MB
EGAF00002048353 cram 392.4 MB
EGAF00002048354 cram 369.3 MB
EGAF00002048355 cram 517.1 MB
EGAF00002048356 cram 530.6 MB
EGAF00002048357 cram 582.4 MB
EGAF00002048358 cram 533.3 MB
EGAF00002048359 cram 579.8 MB
EGAF00002048360 cram 598.8 MB
EGAF00002048361 cram 683.1 MB
EGAF00002048362 cram 649.8 MB
EGAF00002048363 cram 597.6 MB
EGAF00002048364 cram 576.2 MB
EGAF00002048365 cram 618.7 MB
EGAF00002048366 cram 587.6 MB
EGAF00002048367 cram 605.0 MB
EGAF00002048368 cram 520.5 MB
EGAF00002048369 cram 619.6 MB
EGAF00002048370 cram 297.8 MB
EGAF00002048371 cram 256.3 MB
EGAF00002048372 cram 280.0 MB
EGAF00002048373 cram 358.8 MB
EGAF00002048374 cram 424.4 MB
EGAF00002048375 cram 330.4 MB
EGAF00002048376 cram 195.4 MB
EGAF00002048377 cram 368.5 MB
EGAF00002048378 cram 261.4 MB
EGAF00002048379 cram 383.4 MB
EGAF00002048380 cram 361.0 MB
EGAF00002048381 cram 529.1 MB
EGAF00002048382 cram 549.7 MB
EGAF00002048383 cram 584.5 MB
EGAF00002048384 cram 542.7 MB
EGAF00002048385 cram 584.8 MB
EGAF00002048386 cram 583.9 MB
EGAF00002048387 cram 690.3 MB
EGAF00002048388 cram 662.7 MB
EGAF00002048389 cram 605.3 MB
EGAF00002048390 cram 589.6 MB
EGAF00002048391 cram 639.9 MB
EGAF00002048392 cram 594.8 MB
EGAF00002048393 cram 603.7 MB
EGAF00002048394 cram 509.4 MB
EGAF00002048395 cram 640.6 MB
EGAF00002048396 cram 299.6 MB
EGAF00002048397 cram 259.1 MB
EGAF00002048398 cram 282.7 MB
EGAF00002048399 cram 353.4 MB
EGAF00002048400 cram 420.6 MB
EGAF00002048401 cram 333.1 MB
EGAF00002048402 cram 202.9 MB
EGAF00002048403 cram 372.0 MB
EGAF00002048404 cram 263.3 MB
EGAF00002048405 cram 388.0 MB
EGAF00002048406 cram 363.1 MB
EGAF00002048407 cram 512.0 MB
EGAF00002048408 cram 531.3 MB
EGAF00002048409 cram 583.0 MB
EGAF00002048410 cram 538.1 MB
EGAF00002048411 cram 580.6 MB
EGAF00002048412 cram 577.2 MB
EGAF00002048413 cram 678.1 MB
EGAF00002048414 cram 653.0 MB
EGAF00002048415 cram 597.5 MB
EGAF00002048416 cram 580.8 MB
EGAF00002048417 cram 640.1 MB
EGAF00002048418 cram 585.6 MB
EGAF00002048419 cram 591.1 MB
EGAF00002048420 cram 504.7 MB
EGAF00002048421 cram 627.3 MB
EGAF00002048422 cram 297.0 MB
EGAF00002048423 cram 261.1 MB
EGAF00002048424 cram 280.0 MB
EGAF00002048425 cram 349.7 MB
EGAF00002048426 cram 416.6 MB
EGAF00002048427 cram 329.9 MB
EGAF00002048428 cram 197.0 MB
EGAF00002048429 cram 368.7 MB
EGAF00002048430 cram 261.2 MB
EGAF00002048431 cram 384.8 MB
EGAF00002048432 cram 366.9 MB
EGAF00002048433 cram 516.8 MB
EGAF00002048434 cram 542.5 MB
EGAF00002048435 cram 583.8 MB
EGAF00002048436 cram 559.2 MB
EGAF00002048437 cram 584.0 MB
EGAF00002048438 cram 585.4 MB
EGAF00002048439 cram 697.7 MB
EGAF00002048440 cram 698.2 MB
EGAF00002048441 cram 621.0 MB
EGAF00002048442 cram 576.1 MB
EGAF00002048443 cram 661.7 MB
EGAF00002048444 cram 602.1 MB
EGAF00002048445 cram 597.9 MB
EGAF00002048446 cram 519.6 MB
EGAF00002048447 cram 662.8 MB
EGAF00002048448 cram 294.5 MB
EGAF00002048449 cram 256.7 MB
EGAF00002048450 cram 277.8 MB
EGAF00002048451 cram 353.7 MB
EGAF00002048452 cram 417.9 MB
EGAF00002048453 cram 328.4 MB
EGAF00002048454 cram 197.5 MB
EGAF00002048455 cram 368.1 MB
EGAF00002048456 cram 259.2 MB
EGAF00002048457 cram 387.3 MB
EGAF00002048458 cram 357.4 MB
EGAF00002048459 cram 534.5 MB
EGAF00002048460 cram 551.2 MB
EGAF00002048461 cram 590.5 MB
EGAF00002048462 cram 561.1 MB
EGAF00002048463 cram 590.7 MB
EGAF00002048464 cram 590.3 MB
EGAF00002048465 cram 724.0 MB
EGAF00002048466 cram 672.5 MB
EGAF00002048467 cram 627.1 MB
EGAF00002048468 cram 581.1 MB
EGAF00002048469 cram 667.0 MB
EGAF00002048470 cram 594.0 MB
EGAF00002048471 cram 604.2 MB
EGAF00002048472 cram 511.3 MB
EGAF00002048473 cram 676.2 MB
EGAF00002048474 cram 296.9 MB
EGAF00002048475 cram 263.2 MB
EGAF00002048476 cram 279.8 MB
EGAF00002048477 cram 356.8 MB
EGAF00002048478 cram 421.7 MB
EGAF00002048479 cram 328.9 MB
EGAF00002048480 cram 198.8 MB
EGAF00002048481 cram 371.3 MB
EGAF00002048482 cram 260.8 MB
EGAF00002048483 cram 391.1 MB
EGAF00002048484 cram 361.6 MB
EGAF00002048485 cram 486.2 MB
EGAF00002048486 cram 501.9 MB
EGAF00002048487 cram 544.6 MB
EGAF00002048488 cram 503.2 MB
EGAF00002048489 cram 544.0 MB
EGAF00002048490 cram 542.5 MB
EGAF00002048491 cram 635.4 MB
EGAF00002048492 cram 605.8 MB
EGAF00002048493 cram 562.8 MB
EGAF00002048494 cram 537.3 MB
EGAF00002048495 cram 590.3 MB
EGAF00002048496 cram 557.8 MB
EGAF00002048497 cram 552.7 MB
EGAF00002048498 cram 472.6 MB
EGAF00002048499 cram 597.6 MB
EGAF00002048500 cram 277.2 MB
EGAF00002048501 cram 240.1 MB
EGAF00002048502 cram 261.5 MB
EGAF00002048503 cram 331.7 MB
EGAF00002048504 cram 397.2 MB
EGAF00002048505 cram 307.6 MB
EGAF00002048506 cram 185.5 MB
EGAF00002048507 cram 345.5 MB
EGAF00002048508 cram 244.2 MB
EGAF00002048509 cram 360.7 MB
EGAF00002048510 cram 336.6 MB
EGAF00002048511 cram 496.0 MB
EGAF00002048512 cram 507.9 MB
EGAF00002048513 cram 555.7 MB
EGAF00002048514 cram 517.4 MB
EGAF00002048515 cram 563.5 MB
EGAF00002048516 cram 563.2 MB
EGAF00002048517 cram 665.0 MB
EGAF00002048518 cram 618.8 MB
EGAF00002048519 cram 572.0 MB
EGAF00002048520 cram 550.1 MB
EGAF00002048521 cram 612.0 MB
EGAF00002048522 cram 571.1 MB
EGAF00002048523 cram 565.6 MB
EGAF00002048524 cram 484.3 MB
EGAF00002048525 cram 617.9 MB
EGAF00002048526 cram 282.5 MB
EGAF00002048527 cram 245.1 MB
EGAF00002048528 cram 267.0 MB
EGAF00002048529 cram 334.5 MB
EGAF00002048530 cram 398.5 MB
EGAF00002048531 cram 314.2 MB
EGAF00002048532 cram 189.7 MB
EGAF00002048533 cram 351.0 MB
EGAF00002048534 cram 249.8 MB
EGAF00002048535 cram 367.8 MB
EGAF00002048536 cram 343.5 MB
312 Files (147.3 GB)