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Tobacco exposure and somatic mutations in normal human bronchial epithelium

That tobacco smoking causes lung cancer is well-established, but we lack quantitative understanding of its effects on genomes of normal bronchial epithelium. We sequenced whole genomes of 632 colonies derived from single bronchial epithelial cells across 16 subjects. Tobacco smoking is the major influence on mutation burden, adding 1000-10,000+ mutations/cell, massively increasing both between-subject and within-subject variance, and generating several distinct signatures of substitutions and indels. A population of cells in subjects with smoking history had mutation burdens equivalent to that expected for never-smokers: these cells lacked tobacco-specific mutational signatures, were four-fold more frequent in ex-smokers than current smokers, and had significantly longer telomeres than their more mutated counterparts. Driver mutations increased in frequency with age, affecting 4-14% of cells in middle-aged never-smokers. In current smokers, ≥25% of cells carried driver mutations and 0-6% cells had 2 or even 3 drivers. Thus, tobacco smoking increases mutation burden, cell-to-cell heterogeneity and driver mutations, but quitting promotes replenishment of bronchial epithelium from mitotically quiescent cells that have avoided tobacco mutagenesis.

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Studies are experimental investigations of a particular phenomenon, e.g., case-control studies on a particular trait or cancer research projects reporting matching cancer normal genomes from patients.

Study ID Study Title Study Type
EGAS00001001676 Cancer Genomics

This table displays only public information pertaining to the files in the dataset. If you wish to access this dataset, please submit a request. If you already have access to these data files, please consult the download documentation.

ID File Type Size Located in
EGAF00002540044 cram 7.0 GB
EGAF00002540045 cram 7.1 GB
EGAF00002540046 cram 41.7 GB
EGAF00002540047 cram 37.2 GB
EGAF00002540048 cram 39.9 GB
EGAF00002540049 cram 4.5 GB
EGAF00002540050 cram 10.3 GB
EGAF00002540051 cram 5.4 GB
EGAF00002540052 cram 4.1 GB
EGAF00002540053 cram 8.2 GB
EGAF00002540054 cram 4.9 GB
EGAF00002540055 cram 4.2 GB
EGAF00002540056 cram 8.6 GB
EGAF00002540057 cram 5.0 GB
EGAF00002540058 cram 4.3 GB
EGAF00002540059 cram 8.7 GB
EGAF00002540060 cram 5.2 GB
EGAF00002540061 cram 4.5 GB
EGAF00002540062 cram 9.7 GB
EGAF00002540063 cram 5.4 GB
EGAF00002540064 cram 4.4 GB
EGAF00002540065 cram 8.9 GB
EGAF00002540066 cram 5.2 GB
EGAF00002540067 cram 6.9 GB
EGAF00002540068 cram 6.9 GB
EGAF00002540069 cram 6.9 GB
EGAF00002540070 cram 7.0 GB
EGAF00002540071 cram 7.1 GB
EGAF00002540072 cram 7.2 GB
EGAF00002540073 cram 7.4 GB
EGAF00002540074 cram 6.7 GB
EGAF00002540075 cram 6.9 GB
EGAF00002540076 cram 6.9 GB
EGAF00002540077 cram 7.0 GB
EGAF00002540078 cram 7.2 GB
EGAF00002540079 cram 6.6 GB
EGAF00002540080 cram 6.7 GB
EGAF00002540081 cram 7.2 GB
EGAF00002540082 cram 7.2 GB
EGAF00002540083 cram 7.5 GB
EGAF00002540084 cram 7.0 GB
EGAF00002540085 cram 7.0 GB
EGAF00002540086 cram 7.0 GB
EGAF00002540087 cram 7.0 GB
EGAF00002540088 cram 7.3 GB
EGAF00002540089 cram 6.7 GB
EGAF00002540090 cram 6.8 GB
EGAF00002540091 cram 7.1 GB
EGAF00002540092 cram 7.1 GB
EGAF00002540093 cram 7.4 GB
EGAF00002540094 cram 6.9 GB
EGAF00002540095 cram 6.9 GB
EGAF00002540096 cram 7.3 GB
EGAF00002540097 cram 7.3 GB
EGAF00002540098 cram 7.6 GB
EGAF00002540573 bam 51.0 GB
EGAF00002540574 bam 52.1 GB
EGAF00002540575 bam 54.5 GB
EGAF00002540576 bam 57.8 GB
EGAF00002540577 bam 50.8 GB
EGAF00002540578 bam 53.6 GB
EGAF00002540579 bam 50.9 GB
EGAF00002540580 bam 42.1 GB
EGAF00002540581 bam 55.4 GB
EGAF00002540582 bam 46.6 GB
EGAF00002540583 bam 51.5 GB
EGAF00002540584 bam 52.7 GB
EGAF00002540585 bam 49.8 GB
EGAF00002540586 bam 45.8 GB
EGAF00002540587 bam 47.6 GB
EGAF00002540588 bam 54.7 GB
EGAF00002540589 bam 46.1 GB
EGAF00002540590 bam 50.4 GB
EGAF00002540591 bam 52.4 GB
EGAF00002540592 bam 50.4 GB
EGAF00002540593 bam 54.1 GB
EGAF00002540594 bam 24.7 GB
EGAF00002540595 bam 50.8 GB
EGAF00002540596 bam 52.7 GB
EGAF00002540597 bam 49.4 GB
EGAF00002540598 bam 27.9 GB
EGAF00002540599 bam 42.8 GB
EGAF00002540600 bam 38.2 GB
EGAF00002540601 bam 31.4 GB
EGAF00002540602 bam 39.9 GB
EGAF00002540603 bam 30.3 GB
EGAF00002540604 bam 32.6 GB
EGAF00002540605 bam 38.3 GB
EGAF00002540606 bam 26.6 GB
EGAF00002540607 bam 37.5 GB
EGAF00002540608 bam 29.7 GB
EGAF00002540609 bam 33.1 GB
EGAF00002540610 bam 32.7 GB
EGAF00002540611 bam 30.2 GB
EGAF00002540612 bam 32.0 GB
EGAF00002540613 bam 29.0 GB
EGAF00002540614 bam 30.8 GB
EGAF00002540615 bam 32.8 GB
EGAF00002540616 bam 32.1 GB
EGAF00002540617 bam 32.8 GB
EGAF00002540618 bam 30.4 GB
EGAF00002540619 bam 28.0 GB
EGAF00002540620 bam 30.3 GB
EGAF00002540621 bam 30.9 GB
EGAF00002540622 bam 34.6 GB
EGAF00002540623 bam 31.5 GB
EGAF00002540624 bam 26.5 GB
EGAF00002540625 bam 27.8 GB
EGAF00002540626 bam 32.1 GB
EGAF00002540627 bam 33.3 GB
EGAF00002540628 bam 31.8 GB
EGAF00002540629 bam 39.3 GB
EGAF00002540630 bam 73.5 GB
EGAF00002540631 bam 35.1 GB
EGAF00002540632 bam 42.1 GB
EGAF00002540633 bam 24.5 GB
EGAF00002540634 bam 33.8 GB
EGAF00002540635 bam 31.7 GB
EGAF00002540636 bam 29.8 GB
EGAF00002540637 bam 33.1 GB
EGAF00002540638 bam 31.1 GB
EGAF00002540639 bam 30.7 GB
EGAF00002540640 bam 32.7 GB
EGAF00002540641 bam 35.1 GB
EGAF00002540642 bam 33.4 GB
EGAF00002540643 bam 34.0 GB
EGAF00002540644 bam 29.8 GB
EGAF00002540645 bam 33.0 GB
EGAF00002540646 bam 35.1 GB
EGAF00002540647 bam 39.6 GB
EGAF00002540648 bam 36.0 GB
EGAF00002540649 bam 37.2 GB
EGAF00002540650 bam 37.3 GB
EGAF00002540651 bam 28.2 GB
EGAF00002540652 bam 33.7 GB
EGAF00002540653 bam 35.4 GB
EGAF00002540654 bam 32.2 GB
EGAF00002540655 bam 28.8 GB
EGAF00002540656 bam 29.6 GB
EGAF00002540657 bam 27.2 GB
EGAF00002540658 bam 25.6 GB
EGAF00002540659 bam 29.3 GB
EGAF00002540660 bam 22.9 GB
EGAF00002540661 bam 27.7 GB
EGAF00002540662 bam 23.9 GB
EGAF00002540663 bam 17.4 GB
EGAF00002540664 bam 34.9 GB
EGAF00002540665 bam 33.6 GB
EGAF00002540666 bam 24.6 GB
EGAF00002540667 bam 20.9 GB
EGAF00002540668 bam 33.0 GB
EGAF00002540669 bam 27.7 GB
EGAF00002540670 bam 25.5 GB
EGAF00002540671 bam 28.4 GB
EGAF00002540672 bam 30.5 GB
EGAF00002540673 bam 32.1 GB
EGAF00002540674 bam 29.9 GB
EGAF00002540675 bam 29.3 GB
EGAF00002540676 bam 23.1 GB
EGAF00002540677 bam 27.2 GB
EGAF00002540678 bam 31.9 GB
EGAF00002540679 bam 25.1 GB
EGAF00002540680 bam 25.0 GB
EGAF00002540681 bam 30.3 GB
EGAF00002540682 bam 34.4 GB
EGAF00002540683 bam 24.1 GB
EGAF00002540684 bam 36.0 GB
EGAF00002540685 bam 32.7 GB
EGAF00002540686 bam 31.2 GB
EGAF00002540687 bam 25.6 GB
EGAF00002540688 bam 36.5 GB
EGAF00002540689 bam 28.8 GB
EGAF00002540690 bam 21.7 GB
EGAF00002540691 bam 34.2 GB
EGAF00002540692 bam 32.3 GB
EGAF00002540693 bam 34.0 GB
EGAF00002540694 bam 26.3 GB
EGAF00002540695 bam 19.2 GB
EGAF00002540696 bam 32.7 GB
EGAF00002540697 bam 28.5 GB
EGAF00002540698 bam 21.9 GB
EGAF00002540699 bam 31.4 GB
EGAF00002540700 bam 28.1 GB
EGAF00002540701 bam 18.4 GB
EGAF00002540702 bam 25.5 GB
EGAF00002540703 bam 26.9 GB
EGAF00002540704 bam 31.1 GB
EGAF00002540705 bam 19.5 GB
EGAF00002540706 bam 23.2 GB
EGAF00002540707 bam 26.3 GB
EGAF00002540708 bam 31.4 GB
EGAF00002540709 bam 32.4 GB
EGAF00002540710 bam 34.3 GB
EGAF00002540711 bam 29.9 GB
EGAF00002540712 bam 33.2 GB
EGAF00002540713 bam 29.6 GB
EGAF00002540714 bam 29.2 GB
EGAF00002540715 bam 32.2 GB
EGAF00002540716 bam 20.8 GB
EGAF00002540717 bam 36.6 GB
EGAF00002540718 bam 33.2 GB
EGAF00002540719 bam 25.2 GB
EGAF00002540720 bam 17.3 GB
EGAF00002540721 bam 18.2 GB
EGAF00002540722 bam 26.2 GB
EGAF00002540723 bam 26.9 GB
EGAF00002540724 bam 21.3 GB
EGAF00002540725 bam 17.9 GB
EGAF00002540726 bam 20.3 GB
EGAF00002540727 bam 27.2 GB
EGAF00002540728 bam 30.8 GB
EGAF00002540729 bam 29.4 GB
EGAF00002540730 bam 23.4 GB
EGAF00002540731 bam 17.3 GB
EGAF00002540732 bam 30.0 GB
EGAF00002540733 bam 27.1 GB
EGAF00002540734 bam 29.3 GB
EGAF00002540735 bam 27.7 GB
EGAF00002540736 bam 24.7 GB
EGAF00002540737 bam 25.6 GB
EGAF00002540738 bam 34.3 GB
EGAF00002540739 bam 24.9 GB
EGAF00002540740 bam 33.1 GB
EGAF00002540741 bam 16.8 GB
EGAF00002540742 bam 30.7 GB
EGAF00002540743 bam 37.1 GB
EGAF00002540744 bam 23.8 GB
EGAF00002540745 bam 23.9 GB
EGAF00002540746 bam 29.0 GB
EGAF00002540747 bam 28.2 GB
EGAF00002540748 bam 24.1 GB
EGAF00002540749 bam 34.7 GB
EGAF00002540750 bam 27.5 GB
EGAF00002540751 bam 28.7 GB
EGAF00002540752 bam 24.4 GB
EGAF00002540753 bam 21.0 GB
EGAF00002540754 bam 32.0 GB
EGAF00002540755 bam 29.5 GB
EGAF00002540756 bam 36.4 GB
EGAF00002540757 bam 34.5 GB
EGAF00002540758 bam 37.6 GB
EGAF00002540759 bam 36.0 GB
EGAF00002540760 bam 28.7 GB
EGAF00002540761 bam 33.3 GB
EGAF00002540762 bam 34.7 GB
EGAF00002540763 bam 25.4 GB
EGAF00002540764 bam 27.7 GB
EGAF00002540765 bam 23.1 GB
EGAF00002540766 bam 26.2 GB
EGAF00002540767 bam 26.3 GB
EGAF00002540768 bam 34.2 GB
EGAF00002540769 bam 26.4 GB
EGAF00002540770 bam 26.1 GB
EGAF00002540771 bam 32.6 GB
EGAF00002540772 bam 32.7 GB
EGAF00002540773 bam 28.7 GB
EGAF00002540774 bam 21.5 GB
EGAF00002540775 bam 31.4 GB
EGAF00002540776 bam 30.0 GB
EGAF00002540777 bam 26.1 GB
EGAF00002540778 bam 29.5 GB
EGAF00002540779 bam 32.5 GB
EGAF00002540780 bam 29.2 GB
EGAF00002540781 bam 18.5 GB
EGAF00002540782 bam 18.0 GB
EGAF00002540783 bam 26.9 GB
EGAF00002540784 bam 29.7 GB
EGAF00002540785 bam 32.3 GB
EGAF00002540786 bam 36.2 GB
EGAF00002540787 bam 29.3 GB
EGAF00002540788 bam 29.0 GB
EGAF00002540789 bam 28.5 GB
EGAF00002540790 bam 28.5 GB
EGAF00002540791 bam 18.1 GB
EGAF00002540792 bam 23.1 GB
EGAF00002540793 bam 20.1 GB
EGAF00002540794 bam 27.8 GB
EGAF00002540795 bam 20.7 GB
EGAF00002540796 bam 26.9 GB
EGAF00002540797 bam 28.6 GB
EGAF00002540798 bam 19.0 GB
EGAF00002540799 bam 20.8 GB
EGAF00002540800 bam 29.1 GB
EGAF00002540801 bam 28.7 GB
EGAF00002540802 bam 22.8 GB
EGAF00002540803 bam 31.7 GB
EGAF00002540804 bam 25.5 GB
EGAF00002540805 bam 32.7 GB
EGAF00002540806 bam 16.4 GB
EGAF00002540807 bam 17.6 GB
EGAF00002540808 bam 29.0 GB
EGAF00002540809 bam 24.2 GB
EGAF00002540810 bam 17.7 GB
EGAF00002540811 bam 25.0 GB
EGAF00002540812 bam 30.8 GB
EGAF00002540813 bam 29.5 GB
EGAF00002540814 bam 31.9 GB
EGAF00002540815 bam 29.7 GB
EGAF00002540816 bam 29.9 GB
EGAF00002540817 bam 31.8 GB
EGAF00002540818 bam 25.9 GB
EGAF00002540819 bam 25.0 GB
EGAF00002540820 bam 27.3 GB
EGAF00002540821 bam 30.3 GB
EGAF00002540822 bam 26.2 GB
EGAF00002540823 bam 32.9 GB
EGAF00002540824 bam 27.7 GB
EGAF00002540825 bam 28.2 GB
EGAF00002540826 bam 32.8 GB
EGAF00002540827 bam 34.3 GB
EGAF00002540828 bam 41.1 GB
EGAF00002540829 bam 23.2 GB
EGAF00002540830 bam 25.7 GB
EGAF00002540831 bam 23.4 GB
EGAF00002540832 bam 33.6 GB
EGAF00002540833 bam 32.3 GB
EGAF00002540834 bam 24.0 GB
EGAF00002540835 bam 29.9 GB
EGAF00002540836 bam 33.7 GB
EGAF00002540837 bam 31.6 GB
EGAF00002540838 bam 30.2 GB
EGAF00002540839 bam 28.6 GB
EGAF00002540840 bam 30.6 GB
EGAF00002540841 bam 22.9 GB
EGAF00002540842 bam 31.9 GB
EGAF00002540843 bam 24.9 GB
EGAF00002540844 bam 23.3 GB
EGAF00002540845 bam 26.2 GB
EGAF00002540846 bam 26.6 GB
EGAF00002540847 bam 29.0 GB
EGAF00002540848 bam 30.8 GB
EGAF00002540849 bam 27.2 GB
EGAF00002540850 bam 21.1 GB
EGAF00002540851 bam 29.7 GB
EGAF00002540852 bam 27.4 GB
EGAF00002540853 bam 28.7 GB
EGAF00002540854 bam 17.7 GB
EGAF00002540855 bam 19.0 GB
EGAF00002540856 bam 25.5 GB
EGAF00002540857 bam 23.1 GB
EGAF00002540858 bam 30.7 GB
EGAF00002540859 bam 32.7 GB
EGAF00002540860 bam 31.8 GB
EGAF00002540861 bam 30.6 GB
EGAF00002540862 bam 29.7 GB
EGAF00002540863 bam 31.7 GB
EGAF00002540864 bam 17.6 GB
EGAF00002540865 bam 26.0 GB
EGAF00002540866 bam 31.3 GB
EGAF00002540867 bam 30.8 GB
EGAF00002540868 bam 31.3 GB
EGAF00002540869 bam 28.1 GB
EGAF00002540870 bam 22.7 GB
EGAF00002540871 bam 40.0 GB
EGAF00002540872 bam 27.0 GB
EGAF00002540873 bam 32.5 GB
EGAF00002540874 bam 23.7 GB
EGAF00002540875 bam 27.5 GB
EGAF00002540876 bam 25.0 GB
EGAF00002540877 bam 36.7 GB
EGAF00002540878 bam 21.8 GB
EGAF00002540879 bam 25.0 GB
EGAF00002540880 bam 31.3 GB
EGAF00002540881 bam 28.1 GB
EGAF00002540882 bam 40.0 GB
EGAF00002540883 bam 23.7 GB
EGAF00002540884 bam 30.1 GB
EGAF00002540885 bam 31.5 GB
EGAF00002540886 bam 28.2 GB
EGAF00002540887 bam 31.2 GB
EGAF00002540888 bam 36.3 GB
EGAF00002540889 bam 33.8 GB
EGAF00002540890 bam 26.7 GB
EGAF00002540891 bam 32.9 GB
EGAF00002540892 bam 32.2 GB
EGAF00002540893 bam 34.0 GB
EGAF00002540894 bam 60.3 GB
EGAF00002540895 bam 31.3 GB
EGAF00002540896 bam 32.4 GB
EGAF00002540897 bam 29.2 GB
EGAF00002540898 bam 28.7 GB
EGAF00002540899 bam 23.9 GB
EGAF00002540900 bam 35.7 GB
EGAF00002540901 bam 27.2 GB
EGAF00002540902 bam 24.9 GB
EGAF00002540903 bam 33.0 GB
EGAF00002540904 bam 23.9 GB
EGAF00002540905 bam 26.0 GB
EGAF00002540906 bam 27.9 GB
EGAF00002540907 bam 31.6 GB
EGAF00002540908 bam 28.1 GB
EGAF00002540909 bam 32.8 GB
EGAF00002540910 bam 26.7 GB
EGAF00002540911 bam 34.4 GB
EGAF00002540912 bam 26.1 GB
EGAF00002540913 bam 24.1 GB
EGAF00002540914 bam 32.6 GB
EGAF00002540915 bam 30.7 GB
EGAF00002540916 bam 27.9 GB
EGAF00002540917 bam 29.9 GB
EGAF00002540918 bam 32.2 GB
EGAF00002540919 bam 19.2 GB
EGAF00002540920 bam 22.2 GB
EGAF00002540921 bam 27.3 GB
EGAF00002540922 bam 25.1 GB
EGAF00002540923 bam 26.2 GB
EGAF00002540924 bam 20.8 GB
EGAF00002540925 bam 25.8 GB
EGAF00002540926 bam 31.2 GB
EGAF00002540927 bam 27.2 GB
EGAF00002540928 bam 27.2 GB
EGAF00002540929 bam 28.2 GB
EGAF00002540930 bam 23.9 GB
EGAF00002540931 bam 17.1 GB
EGAF00002540932 bam 31.4 GB
EGAF00002540933 bam 17.5 GB
EGAF00002540934 bam 24.6 GB
EGAF00002540935 bam 28.6 GB
EGAF00002540936 bam 23.8 GB
EGAF00002540937 bam 26.8 GB
EGAF00002540938 bam 27.7 GB
EGAF00002540939 bam 20.7 GB
EGAF00002540940 bam 28.7 GB
EGAF00002540941 bam 26.8 GB
EGAF00002540942 bam 30.0 GB
EGAF00002540943 bam 30.0 GB
EGAF00002540944 bam 22.9 GB
EGAF00002540945 bam 36.4 GB
EGAF00002540946 bam 31.1 GB
EGAF00002540947 bam 22.2 GB
EGAF00002540948 bam 30.4 GB
EGAF00002540949 bam 25.6 GB
EGAF00002540950 bam 40.9 GB
EGAF00002540951 bam 29.1 GB
EGAF00002540952 bam 35.9 GB
EGAF00002540953 bam 29.2 GB
EGAF00002540954 bam 28.8 GB
EGAF00002540955 bam 31.1 GB
EGAF00002540956 bam 34.6 GB
EGAF00002540957 bam 33.1 GB
EGAF00002540958 bam 33.1 GB
EGAF00002540959 bam 30.9 GB
EGAF00002540960 bam 24.5 GB
EGAF00002540961 bam 28.0 GB
EGAF00002540962 bam 33.6 GB
EGAF00002540963 bam 32.1 GB
EGAF00002540964 bam 29.3 GB
EGAF00002540965 bam 34.0 GB
EGAF00002540966 bam 28.4 GB
EGAF00002540967 bam 31.1 GB
EGAF00002540968 bam 34.0 GB
EGAF00002540969 bam 32.3 GB
EGAF00002540970 bam 29.4 GB
EGAF00002540971 bam 34.7 GB
EGAF00002540972 bam 31.7 GB
EGAF00002540973 bam 31.5 GB
EGAF00002540974 bam 34.6 GB
EGAF00002540975 bam 28.0 GB
EGAF00002540976 bam 28.9 GB
EGAF00002540977 bam 31.9 GB
EGAF00002540978 bam 30.8 GB
EGAF00002540979 bam 31.8 GB
EGAF00002540980 bam 31.6 GB
EGAF00002540981 bam 31.0 GB
EGAF00002540982 bam 32.1 GB
EGAF00002540983 bam 28.2 GB
EGAF00002540984 bam 27.8 GB
EGAF00002540985 bam 25.8 GB
EGAF00002540986 bam 27.9 GB
EGAF00002540987 bam 33.0 GB
EGAF00002540988 bam 30.7 GB
EGAF00002540989 bam 30.3 GB
EGAF00002540990 bam 27.8 GB
EGAF00002540991 bam 28.1 GB
EGAF00002540992 bam 28.3 GB
EGAF00002540993 bam 29.8 GB
EGAF00002540994 bam 32.8 GB
EGAF00002540995 bam 30.1 GB
EGAF00002540996 bam 26.2 GB
EGAF00002540997 bam 25.8 GB
EGAF00002540998 bam 30.1 GB
EGAF00002540999 bam 28.0 GB
EGAF00002541000 bam 31.3 GB
EGAF00002541001 bam 34.4 GB
EGAF00002541002 bam 30.2 GB
EGAF00002541003 bam 35.9 GB
EGAF00002541004 bam 28.4 GB
EGAF00002541005 bam 33.7 GB
EGAF00002541006 bam 24.1 GB
EGAF00002541007 bam 31.8 GB
EGAF00002541008 bam 32.4 GB
EGAF00002541009 bam 29.3 GB
EGAF00002541010 bam 28.6 GB
EGAF00002541011 bam 32.8 GB
EGAF00002541012 bam 27.0 GB
EGAF00002541013 bam 31.9 GB
EGAF00002541014 bam 30.6 GB
EGAF00002541015 bam 33.7 GB
EGAF00002541016 bam 33.0 GB
EGAF00002541017 bam 30.5 GB
EGAF00002541018 bam 31.8 GB
EGAF00002541019 bam 33.1 GB
EGAF00002541020 bam 22.3 GB
EGAF00002541021 bam 32.0 GB
EGAF00002541022 bam 32.5 GB
EGAF00002541023 bam 32.6 GB
EGAF00002541024 bam 31.9 GB
EGAF00002541025 bam 31.8 GB
EGAF00002541026 bam 29.5 GB
EGAF00002541027 bam 26.3 GB
EGAF00002541028 bam 29.7 GB
EGAF00002541029 bam 29.0 GB
EGAF00002541030 bam 36.6 GB
EGAF00002541031 bam 32.4 GB
EGAF00002541032 bam 30.3 GB
EGAF00002541033 bam 32.1 GB
EGAF00002541034 bam 32.7 GB
EGAF00002541035 bam 32.1 GB
EGAF00002541036 bam 31.8 GB
EGAF00002541037 bam 26.4 GB
EGAF00002541038 bam 30.1 GB
EGAF00002541039 bam 30.7 GB
EGAF00002541040 bam 32.3 GB
EGAF00002541041 bam 29.1 GB
EGAF00002541042 bam 30.5 GB
EGAF00002541043 bam 36.2 GB
EGAF00002541044 bam 28.3 GB
EGAF00002541045 bam 29.2 GB
EGAF00002541046 bam 29.2 GB
EGAF00002541047 bam 41.0 GB
EGAF00002541048 bam 32.2 GB
EGAF00002541049 bam 29.1 GB
EGAF00002541050 bam 29.4 GB
EGAF00002541051 bam 24.0 GB
EGAF00002541052 bam 30.3 GB
EGAF00002541053 bam 30.1 GB
EGAF00002541054 bam 32.0 GB
EGAF00002541055 bam 32.8 GB
EGAF00002541056 bam 29.2 GB
EGAF00002541057 bam 32.6 GB
EGAF00002541058 bam 28.3 GB
EGAF00002541059 bam 23.6 GB
EGAF00002541060 bam 31.3 GB
EGAF00002541061 bam 24.5 GB
EGAF00002541062 bam 41.8 GB
EGAF00002541063 bam 32.8 GB
EGAF00002541064 bam 31.2 GB
EGAF00002541065 bam 30.4 GB
EGAF00002541066 bam 29.5 GB
EGAF00002541067 bam 40.2 GB
EGAF00002541068 bam 40.0 GB
EGAF00002541069 bam 29.3 GB
EGAF00002541070 bam 31.3 GB
EGAF00002541071 bam 28.5 GB
EGAF00002541072 bam 32.5 GB
EGAF00002541073 bam 30.5 GB
EGAF00002541074 bam 30.2 GB
EGAF00002541075 bam 35.0 GB
EGAF00002541076 bam 31.7 GB
EGAF00002541077 bam 30.6 GB
EGAF00002541078 bam 29.0 GB
EGAF00002541079 bam 29.7 GB
EGAF00002541080 bam 35.8 GB
EGAF00002541081 bam 34.4 GB
EGAF00002541082 bam 32.5 GB
EGAF00002541083 bam 35.3 GB
EGAF00002541084 bam 26.6 GB
EGAF00002541085 bam 17.4 GB
EGAF00002541086 bam 27.3 GB
EGAF00002541087 bam 27.1 GB
EGAF00002541088 bam 25.3 GB
EGAF00002541089 bam 20.8 GB
EGAF00002541090 bam 24.6 GB
EGAF00002541091 bam 31.7 GB
EGAF00002541092 bam 42.3 GB
EGAF00002541093 bam 30.0 GB
EGAF00002541094 bam 30.6 GB
EGAF00002541095 bam 31.2 GB
EGAF00002541096 bam 22.5 GB
EGAF00002541097 bam 29.7 GB
EGAF00002541098 bam 29.4 GB
EGAF00002541099 bam 28.8 GB
EGAF00002541100 bam 32.4 GB
EGAF00002541101 bam 29.9 GB
EGAF00002541102 bam 29.6 GB
EGAF00002541103 bam 30.3 GB
EGAF00002541104 bam 28.8 GB
EGAF00002541105 bam 30.7 GB
EGAF00002541106 bam 26.9 GB
EGAF00002541107 bam 30.9 GB
EGAF00002541108 bam 31.9 GB
EGAF00002541109 bam 28.0 GB
EGAF00002541110 bam 30.5 GB
EGAF00002541111 bam 33.2 GB
EGAF00002541112 bam 30.7 GB
EGAF00002541113 bam 31.2 GB
EGAF00002541114 bam 32.5 GB
EGAF00002541115 bam 30.2 GB
EGAF00002541116 bam 32.1 GB
EGAF00002541117 bam 28.4 GB
EGAF00002541118 bam 30.2 GB
EGAF00002541119 bam 32.6 GB
EGAF00002541120 bam 34.3 GB
EGAF00002541121 bam 34.9 GB
EGAF00002541122 bam 30.9 GB
EGAF00002541123 bam 31.8 GB
EGAF00002541124 bam 28.8 GB
EGAF00002541125 bam 34.9 GB
EGAF00002541126 bam 30.4 GB
EGAF00002541127 bam 29.8 GB
EGAF00002541128 bam 31.3 GB
EGAF00002541129 bam 28.1 GB
EGAF00002541130 bam 27.1 GB
EGAF00002541131 bam 27.7 GB
EGAF00002541132 bam 18.0 GB
EGAF00002541133 bam 30.2 GB
EGAF00002541134 bam 31.9 GB
EGAF00002541135 bam 32.3 GB
EGAF00002541136 bam 28.2 GB
EGAF00002541137 bam 29.8 GB
EGAF00002541138 bam 40.7 GB
EGAF00002541139 bam 35.2 GB
EGAF00002541140 bam 37.7 GB
EGAF00002541141 bam 32.8 GB
EGAF00002541142 bam 35.1 GB
EGAF00002541143 bam 35.7 GB
EGAF00002541144 bam 27.6 GB
EGAF00002541145 bam 28.5 GB
EGAF00002541146 bam 35.2 GB
EGAF00002541147 bam 36.6 GB
EGAF00002541148 bam 30.1 GB
EGAF00002541149 bam 25.6 GB
EGAF00002541150 bam 24.5 GB
EGAF00002541151 bam 27.9 GB
EGAF00002541152 bam 33.6 GB
EGAF00002541153 bam 29.3 GB
EGAF00002541154 bam 29.0 GB
EGAF00002541155 bam 32.1 GB
EGAF00002541156 bam 27.5 GB
EGAF00002541157 bam 32.3 GB
EGAF00002541158 bam 33.6 GB
EGAF00002541159 bam 30.5 GB
EGAF00002541160 bam 27.9 GB
EGAF00002541161 bam 31.8 GB
EGAF00002541162 bam 28.5 GB
EGAF00002541163 bam 29.4 GB
EGAF00002541164 bam 30.2 GB
EGAF00002541165 bam 28.2 GB
EGAF00002541166 bam 34.7 GB
EGAF00002541167 bam 29.3 GB
EGAF00002541168 bam 29.8 GB
EGAF00002541169 bam 24.6 GB
EGAF00002541170 bam 34.0 GB
EGAF00002541171 bam 22.7 GB
EGAF00002541172 bam 27.5 GB
EGAF00002541173 bam 33.1 GB
EGAF00002541174 bam 28.2 GB
EGAF00002541175 bam 32.5 GB
EGAF00002541176 bam 30.0 GB
EGAF00002541177 bam 34.5 GB
EGAF00002541178 bam 33.1 GB
EGAF00002541179 bam 35.1 GB
EGAF00002541180 bam 32.2 GB
EGAF00002541181 bam 29.4 GB
EGAF00002541182 bam 34.9 GB
EGAF00002541183 bam 20.5 GB
EGAF00002541184 bam 33.0 GB
EGAF00002541185 bam 28.5 GB
EGAF00002541186 bam 28.4 GB
EGAF00002541187 bam 20.9 GB
EGAF00002541188 bam 29.6 GB
EGAF00002541189 bam 29.4 GB
EGAF00002541190 bam 31.0 GB
EGAF00002541191 bam 30.0 GB
EGAF00002541192 bam 28.8 GB
EGAF00002541193 bam 32.3 GB
EGAF00002541194 bam 27.5 GB
EGAF00002541195 bam 30.6 GB
EGAF00002541196 bam 31.0 GB
EGAF00002541197 bam 29.3 GB
EGAF00002541198 bam 34.9 GB
EGAF00002541199 bam 33.4 GB
EGAF00002541200 bam 31.1 GB
EGAF00002541201 bam 33.2 GB
EGAF00002541202 bam 32.8 GB
EGAF00002541203 bam 32.8 GB
EGAF00002541204 bam 35.3 GB
687 Files (19.7 TB)