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The mutational landscape of normal human endometrial epithelium - Additional Samples

All normal somatic cells are thought to acquire mutations but understanding of the rates, patterns, causes and consequences of somatic mutation in normal cells is limited. Uterine endometrium adopts multiple physiological states over a lifetime and is lined by a gland-forming epithelium. Whole genome sequencing of normal endometrial glands from women aged 19 to 81 years showed them to be clonal cell populations derived from recent common ancestors, with total mutation burdens that increase with age at ~29 base substitutions/year and which are many-fold lower than endometrial cancers. Normal endometrial glands frequently carry driver mutations in cancer genes. Driver mutation burdens increase with age and correlate negatively with parity. Phylogenetic trees of normal endometrial glands constructed using whole genome sequences indicated that clones with drivers often originate during the first decades and spread to colonise the endometrial epithelial lining. The results show that driver mutation landscapes differ between normal cell types, perhaps shaped by differences in normal tissue physiology, and suggest that the procession of neoplastic changes leading to endometrial cancer is initiated early in life.

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Studies are experimental investigations of a particular phenomenon, e.g., case-control studies on a particular trait or cancer research projects reporting matching cancer normal genomes from patients.

Study ID Study Title Study Type
EGAS00001002471 Cancer Genomics

This table displays only public information pertaining to the files in the dataset. If you wish to access this dataset, please submit a request. If you already have access to these data files, please consult the download documentation.

ID File Type Size Located in
EGAF00002544572 cram 4.6 GB
EGAF00002544573 cram 5.5 GB
EGAF00002544574 cram 4.9 GB
EGAF00002544575 cram 5.4 GB
EGAF00002544576 cram 6.3 GB
EGAF00002544577 cram 4.1 GB
EGAF00002544578 cram 4.6 GB
EGAF00002544579 cram 5.5 GB
EGAF00002544580 cram 4.9 GB
EGAF00002544581 cram 5.4 GB
EGAF00002544582 cram 6.2 GB
EGAF00002544583 cram 4.0 GB
EGAF00002544584 cram 4.6 GB
EGAF00002544585 cram 5.5 GB
EGAF00002544586 cram 4.9 GB
EGAF00002544587 cram 4.7 GB
EGAF00002544588 cram 4.8 GB
EGAF00002544589 cram 5.5 GB
EGAF00002544590 cram 5.1 GB
EGAF00002544591 cram 6.6 GB
EGAF00002544592 cram 4.2 GB
EGAF00002544593 cram 4.5 GB
EGAF00002544594 cram 4.5 GB
EGAF00002544595 cram 5.2 GB
EGAF00002544596 cram 4.8 GB
EGAF00002544597 cram 6.3 GB
EGAF00002544598 cram 4.1 GB
EGAF00002544599 cram 4.4 GB
EGAF00002544600 cram 4.4 GB
EGAF00002544601 cram 5.1 GB
EGAF00002544602 cram 4.7 GB
EGAF00002544603 cram 6.1 GB
EGAF00002544604 cram 4.2 GB
EGAF00002544605 cram 4.4 GB
EGAF00002544606 cram 4.4 GB
EGAF00002544607 cram 5.1 GB
EGAF00002544608 cram 4.7 GB
EGAF00002544609 cram 6.1 GB
EGAF00002544610 cram 4.2 GB
EGAF00002544611 cram 4.4 GB
EGAF00002544612 cram 4.4 GB
EGAF00002544613 cram 5.1 GB
EGAF00002544614 cram 4.7 GB
EGAF00002544615 cram 6.1 GB
EGAF00002544616 cram 5.5 GB
EGAF00002544617 cram 4.5 GB
EGAF00002544618 cram 5.1 GB
EGAF00002544619 cram 5.4 GB
EGAF00002544620 cram 6.1 GB
EGAF00002544621 cram 8.5 GB
EGAF00002544622 cram 8.2 GB
EGAF00002544623 cram 7.5 GB
EGAF00002544624 cram 8.6 GB
EGAF00002544625 cram 8.3 GB
EGAF00002544626 cram 8.1 GB
EGAF00002544627 cram 7.4 GB
EGAF00002544628 cram 8.4 GB
EGAF00002544629 cram 8.5 GB
EGAF00002544630 cram 8.3 GB
EGAF00002544631 cram 7.5 GB
EGAF00002544632 cram 8.6 GB
EGAF00002544633 cram 8.5 GB
EGAF00002544634 cram 8.3 GB
EGAF00002544635 cram 7.5 GB
EGAF00002544636 cram 8.6 GB
EGAF00002544637 cram 5.6 GB
EGAF00002544638 cram 5.5 GB
EGAF00002544639 cram 4.4 GB
EGAF00002544640 cram 4.8 GB
EGAF00002544641 cram 5.3 GB
EGAF00002544642 cram 4.4 GB
EGAF00002544643 cram 5.5 GB
EGAF00002544644 cram 5.5 GB
EGAF00002544645 cram 5.6 GB
EGAF00002544646 cram 6.4 GB
EGAF00002544647 cram 4.9 GB
EGAF00002544648 cram 4.9 GB
EGAF00002544649 cram 6.3 GB
EGAF00002544650 cram 4.7 GB
EGAF00002544651 cram 4.8 GB
EGAF00002544652 cram 6.2 GB
EGAF00002544653 cram 4.6 GB
EGAF00002544654 cram 4.6 GB
EGAF00002544655 cram 6.1 GB
EGAF00002544656 cram 4.6 GB
EGAF00002544657 cram 4.6 GB
EGAF00002544658 cram 6.1 GB
EGAF00002544659 cram 4.5 GB
EGAF00002544660 cram 4.6 GB
EGAF00002544661 cram 6.5 GB
EGAF00002544662 cram 4.9 GB
EGAF00002544663 cram 4.9 GB
EGAF00002544664 cram 6.0 GB
EGAF00002544665 cram 6.1 GB
EGAF00002544666 cram 4.6 GB
EGAF00002544667 cram 5.9 GB
EGAF00002544668 cram 6.7 GB
EGAF00002544669 cram 4.5 GB
EGAF00002544670 cram 4.9 GB
EGAF00002544671 cram 5.8 GB
EGAF00002544672 cram 4.7 GB
EGAF00002544673 cram 5.1 GB
EGAF00002544674 cram 4.8 GB
EGAF00002544675 cram 6.1 GB
EGAF00002544676 cram 6.5 GB
EGAF00002544677 cram 5.8 GB
EGAF00002544678 cram 6.8 GB
EGAF00002544679 cram 4.4 GB
EGAF00002544680 cram 4.9 GB
EGAF00002544681 cram 6.3 GB
EGAF00002544682 cram 6.6 GB
EGAF00002544683 cram 5.9 GB
EGAF00002544684 cram 7.0 GB
EGAF00002544685 cram 4.4 GB
EGAF00002544686 cram 4.9 GB
EGAF00002544687 cram 6.2 GB
EGAF00002544688 cram 6.6 GB
EGAF00002544689 cram 5.9 GB
EGAF00002544690 cram 6.9 GB
EGAF00002544691 cram 4.4 GB
EGAF00002544692 cram 4.9 GB
EGAF00002544693 cram 6.2 GB
EGAF00002544694 cram 6.7 GB
EGAF00002544695 cram 5.9 GB
EGAF00002544696 cram 6.9 GB
EGAF00002544697 cram 4.5 GB
EGAF00002544698 cram 5.0 GB
EGAF00002544699 cram 6.3 GB
EGAF00002544700 cram 6.7 GB
EGAF00002544701 cram 5.9 GB
EGAF00002544702 cram 7.0 GB
EGAF00002544703 cram 5.4 GB
EGAF00002544704 cram 6.2 GB
EGAF00002544705 cram 4.0 GB
EGAF00002544706 cram 4.5 GB
EGAF00002544707 cram 5.5 GB
EGAF00002544708 cram 4.9 GB
EGAF00002544709 cram 5.4 GB
EGAF00002544710 cram 6.2 GB
EGAF00002544711 cram 4.0 GB
EGAF00002544712 cram 4.6 GB
EGAF00002544713 cram 5.6 GB
EGAF00002544714 cram 4.9 GB
EGAF00002544715 cram 5.4 GB
EGAF00002544716 cram 6.3 GB
EGAF00002544717 cram 4.0 GB
EGAF00002544718 cram 4.5 GB
EGAF00002544719 cram 5.4 GB
EGAF00002544720 cram 4.8 GB
EGAF00002544721 cram 5.3 GB
EGAF00002544722 cram 6.1 GB
EGAF00002544723 cram 4.0 GB
EGAF00002544724 cram 4.6 GB
EGAF00002544725 cram 4.8 GB
EGAF00002544726 cram 4.8 GB
EGAF00002544727 cram 5.5 GB
EGAF00002544728 cram 5.2 GB
EGAF00002544729 cram 6.6 GB
EGAF00002544730 cram 4.5 GB
EGAF00002544731 cram 4.5 GB
EGAF00002544732 cram 4.5 GB
EGAF00002544733 cram 5.0 GB
EGAF00002544734 cram 4.4 GB
EGAF00002544735 cram 4.5 GB
EGAF00002544736 cram 5.0 GB
EGAF00002544737 cram 4.5 GB
EGAF00002544738 cram 4.5 GB
EGAF00002544739 cram 5.0 GB
EGAF00002544740 cram 4.5 GB
EGAF00002544741 cram 4.6 GB
EGAF00002544742 cram 5.1 GB
EGAF00002544743 cram 5.5 GB
EGAF00002544744 cram 4.4 GB
EGAF00002544745 cram 4.3 GB
EGAF00002544746 cram 4.4 GB
EGAF00002544747 cram 4.4 GB
EGAF00002544748 cram 4.7 GB
EGAF00002544749 cram 4.8 GB
EGAF00002544750 cram 4.7 GB
EGAF00002544751 cram 4.7 GB
EGAF00002544752 cram 5.5 GB
EGAF00002544753 cram 5.4 GB
EGAF00002544754 cram 4.8 GB
EGAF00002544755 cram 5.1 GB
EGAF00002544756 cram 5.1 GB
EGAF00002544757 cram 5.1 GB
EGAF00002544758 cram 5.0 GB
EGAF00002544759 cram 4.9 GB
EGAF00002544760 cram 4.3 GB
EGAF00002544761 cram 4.7 GB
EGAF00002544762 cram 5.3 GB
EGAF00002544763 cram 4.4 GB
EGAF00002544764 cram 5.5 GB
EGAF00002544765 cram 5.4 GB
EGAF00002544766 cram 4.3 GB
EGAF00002544767 cram 4.7 GB
EGAF00002544768 cram 5.3 GB
EGAF00002544769 cram 4.4 GB
EGAF00002544770 cram 5.4 GB
EGAF00002544771 cram 5.4 GB
EGAF00002544772 cram 4.2 GB
EGAF00002544773 cram 4.6 GB
EGAF00002544774 cram 5.2 GB
EGAF00002544775 cram 4.3 GB
EGAF00002544776 cram 5.5 GB
EGAF00002544777 cram 5.5 GB
EGAF00002544778 cram 4.4 GB
EGAF00002544779 cram 4.7 GB
EGAF00002544780 cram 5.4 GB
EGAF00002544781 cram 4.4 GB
EGAF00002544782 cram 5.4 GB
EGAF00002544783 cram 5.4 GB
EGAF00002544784 cram 4.3 GB
EGAF00002544785 cram 4.7 GB
EGAF00002544786 cram 5.2 GB
EGAF00002544787 cram 4.4 GB
EGAF00002544788 cram 5.4 GB
EGAF00002544789 cram 9.2 GB
EGAF00002544790 cram 4.7 GB
EGAF00002544791 cram 4.9 GB
EGAF00002544792 cram 5.7 GB
EGAF00002544793 cram 4.6 GB
EGAF00002544794 cram 5.0 GB
EGAF00002544795 cram 9.0 GB
EGAF00002544796 cram 4.6 GB
EGAF00002544797 cram 4.8 GB
EGAF00002544798 cram 5.6 GB
EGAF00002544799 cram 4.6 GB
EGAF00002544800 cram 5.0 GB
EGAF00002544801 cram 8.9 GB
EGAF00002544802 cram 4.6 GB
EGAF00002544803 cram 5.0 GB
EGAF00002544804 cram 5.8 GB
EGAF00002544805 cram 4.7 GB
EGAF00002544806 cram 5.2 GB
EGAF00002544807 cram 9.3 GB
EGAF00002544808 cram 4.8 GB
EGAF00002544809 cram 4.9 GB
EGAF00002544810 cram 5.7 GB
EGAF00002544811 cram 4.7 GB
EGAF00002544812 cram 5.1 GB
EGAF00002544813 cram 9.2 GB
EGAF00002544814 cram 4.7 GB
EGAF00002544815 cram 4.9 GB
EGAF00002544816 cram 5.7 GB
EGAF00002544817 cram 4.7 GB
EGAF00002544818 cram 5.3 GB
EGAF00002544819 cram 5.8 GB
EGAF00002544820 cram 7.4 GB
EGAF00002544821 cram 7.9 GB
EGAF00002544822 cram 7.0 GB
EGAF00002544823 cram 8.2 GB
EGAF00002544824 cram 8.2 GB
EGAF00002544825 cram 8.3 GB
EGAF00002544826 cram 6.3 GB
EGAF00002544827 cram 8.1 GB
EGAF00002544828 cram 9.2 GB
EGAF00002544829 cram 6.1 GB
EGAF00002544830 cram 6.3 GB
EGAF00002544831 cram 6.3 GB
EGAF00002544832 cram 4.8 GB
EGAF00002544833 cram 6.2 GB
EGAF00002544834 cram 7.0 GB
EGAF00002544835 cram 4.6 GB
EGAF00002544836 cram 6.9 GB
EGAF00002544837 cram 6.8 GB
EGAF00002544838 cram 5.2 GB
EGAF00002544839 cram 6.7 GB
EGAF00002544840 cram 7.6 GB
EGAF00002544841 cram 5.0 GB
EGAF00002544842 cram 6.2 GB
EGAF00002544843 cram 6.2 GB
EGAF00002544844 cram 4.8 GB
EGAF00002544845 cram 6.1 GB
EGAF00002544846 cram 6.9 GB
EGAF00002544847 cram 5.5 GB
EGAF00002544848 cram 5.5 GB
EGAF00002544849 cram 5.5 GB
EGAF00002544850 cram 5.5 GB
EGAF00002544851 cram 5.5 GB
EGAF00002544852 cram 10.3 GB
EGAF00002544853 cram 10.3 GB
EGAF00002544854 cram 10.5 GB
EGAF00002544855 cram 4.9 GB
EGAF00002544856 cram 4.9 GB
EGAF00002544857 cram 5.8 GB
EGAF00002544858 cram 5.6 GB
EGAF00002544859 cram 4.6 GB
EGAF00002544860 cram 5.2 GB
EGAF00002544861 cram 5.5 GB
EGAF00002544862 cram 6.2 GB
EGAF00002544863 cram 5.9 GB
EGAF00002544864 cram 5.6 GB
EGAF00002544865 cram 4.6 GB
EGAF00002544866 cram 5.2 GB
EGAF00002544867 cram 5.5 GB
EGAF00002544868 cram 6.3 GB
EGAF00002544869 cram 5.8 GB
EGAF00002544870 cram 5.5 GB
EGAF00002544871 cram 4.5 GB
EGAF00002544872 cram 5.1 GB
EGAF00002544873 cram 5.4 GB
EGAF00002544874 cram 6.2 GB
EGAF00002544875 cram 5.7 GB
EGAF00002544876 cram 5.1 GB
EGAF00002544877 cram 4.1 GB
EGAF00002544878 cram 4.7 GB
EGAF00002544879 cram 5.1 GB
EGAF00002544880 cram 5.7 GB
EGAF00002544881 cram 5.4 GB
EGAF00002544882 cram 5.1 GB
EGAF00002544883 cram 4.1 GB
EGAF00002544884 cram 4.7 GB
EGAF00002544885 cram 5.1 GB
EGAF00002544886 cram 5.7 GB
EGAF00002544887 cram 4.7 GB
EGAF00002544888 cram 4.7 GB
EGAF00002544889 cram 5.2 GB
EGAF00002544890 cram 4.5 GB
EGAF00002544891 cram 4.5 GB
EGAF00002544892 cram 5.0 GB
EGAF00002544893 cram 5.1 GB
EGAF00002544894 cram 4.8 GB
EGAF00002544895 cram 5.2 GB
EGAF00002544896 cram 3.8 GB
EGAF00002544897 cram 4.9 GB
EGAF00002544898 cram 5.9 GB
EGAF00002544899 cram 5.2 GB
EGAF00002544900 cram 4.9 GB
EGAF00002544901 cram 5.2 GB
EGAF00002544902 cram 3.8 GB
EGAF00002544903 cram 5.0 GB
EGAF00002544904 cram 5.9 GB
EGAF00002544905 cram 4.6 GB
EGAF00002544906 cram 6.2 GB
EGAF00002544907 cram 6.2 GB
EGAF00002544908 cram 4.7 GB
EGAF00002544909 cram 6.1 GB
EGAF00002544910 cram 6.8 GB
EGAF00002544911 cram 4.5 GB
EGAF00002544912 cram 5.6 GB
EGAF00002544913 cram 6.2 GB
EGAF00002544914 cram 5.8 GB
EGAF00002544915 cram 5.4 GB
EGAF00002544916 cram 5.3 GB
EGAF00002544917 cram 5.4 GB
EGAF00002544918 cram 5.8 GB
EGAF00002544919 cram 6.3 GB
EGAF00002544920 cram 5.9 GB
EGAF00002544921 cram 5.6 GB
EGAF00002544922 cram 5.5 GB
EGAF00002544923 cram 5.5 GB
EGAF00002544924 cram 5.6 GB
EGAF00002544925 cram 6.1 GB
EGAF00002544926 cram 5.7 GB
EGAF00002544927 cram 5.4 GB
EGAF00002544928 cram 5.2 GB
EGAF00002544929 cram 5.3 GB
EGAF00002544930 cram 11.7 GB
EGAF00002544931 cram 11.2 GB
EGAF00002544932 cram 9.8 GB
EGAF00002544933 cram 11.9 GB
EGAF00002544934 cram 5.3 GB
EGAF00002544935 cram 5.0 GB
EGAF00002544936 cram 5.3 GB
EGAF00002544937 cram 4.0 GB
EGAF00002544938 cram 5.1 GB
EGAF00002544939 cram 6.1 GB
EGAF00002544940 cram 5.3 GB
EGAF00002544941 cram 4.9 GB
EGAF00002544942 cram 5.3 GB
EGAF00002544943 cram 3.9 GB
EGAF00002544944 cram 5.1 GB
EGAF00002544945 cram 6.0 GB
EGAF00002544946 cram 5.4 GB
EGAF00002544947 cram 5.1 GB
EGAF00002544948 cram 5.4 GB
EGAF00002544949 cram 4.1 GB
EGAF00002544950 cram 5.2 GB
EGAF00002544951 cram 6.2 GB
EGAF00002544952 cram 5.4 GB
EGAF00002544953 cram 5.1 GB
EGAF00002544954 cram 5.4 GB
EGAF00002544955 cram 4.0 GB
EGAF00002544956 cram 5.2 GB
EGAF00002544957 cram 6.2 GB
EGAF00002544958 cram 6.0 GB
EGAF00002544959 cram 5.9 GB
EGAF00002544960 cram 5.9 GB
EGAF00002544961 cram 5.9 GB
EGAF00002544962 cram 5.9 GB
EGAF00002544963 cram 5.1 GB
EGAF00002544964 cram 9.1 GB
EGAF00002544965 cram 4.7 GB
EGAF00002544966 cram 5.5 GB
EGAF00002544967 cram 7.2 GB
EGAF00002544968 cram 4.4 GB
EGAF00002544969 cram 5.2 GB
EGAF00002544970 cram 6.2 GB
EGAF00002544971 cram 5.0 GB
EGAF00002544972 cram 5.6 GB
EGAF00002544973 cram 7.0 GB
EGAF00002544974 cram 4.4 GB
EGAF00002544975 cram 5.3 GB
EGAF00002544976 cram 6.2 GB
EGAF00002544977 cram 5.0 GB
EGAF00002544978 cram 6.1 GB
EGAF00002544979 cram 7.7 GB
EGAF00002544980 cram 4.9 GB
EGAF00002544981 cram 5.8 GB
EGAF00002544982 cram 6.8 GB
EGAF00002544983 cram 5.4 GB
EGAF00002544984 cram 6.0 GB
EGAF00002544985 cram 7.6 GB
EGAF00002544986 cram 4.8 GB
EGAF00002544987 cram 5.7 GB
EGAF00002544988 cram 6.7 GB
EGAF00002544989 cram 5.3 GB
EGAF00002544990 cram 5.8 GB
EGAF00002544991 cram 7.3 GB
EGAF00002544992 cram 4.6 GB
EGAF00002544993 cram 5.5 GB
EGAF00002544994 cram 6.4 GB
EGAF00002544995 cram 5.1 GB
EGAF00002544996 cram 5.9 GB
EGAF00002544997 cram 7.4 GB
EGAF00002544998 cram 4.7 GB
EGAF00002544999 cram 5.6 GB
EGAF00002545000 cram 6.6 GB
EGAF00002545001 cram 5.2 GB
EGAF00002545002 cram 5.9 GB
EGAF00002545003 cram 6.5 GB
EGAF00002545004 cram 6.1 GB
EGAF00002545005 cram 5.7 GB
EGAF00002545006 cram 5.7 GB
EGAF00002545007 cram 5.6 GB
EGAF00002545008 cram 5.9 GB
EGAF00002545009 cram 6.6 GB
EGAF00002545010 cram 6.2 GB
EGAF00002545011 cram 5.8 GB
EGAF00002545012 cram 5.7 GB
EGAF00002545013 cram 5.7 GB
EGAF00002545014 cram 6.0 GB
EGAF00002545015 cram 6.6 GB
EGAF00002545016 cram 6.2 GB
EGAF00002545017 cram 5.8 GB
EGAF00002545018 cram 5.8 GB
EGAF00002545019 cram 5.7 GB
EGAF00002545020 cram 4.3 GB
EGAF00002545021 cram 11.5 GB
EGAF00002545022 cram 10.1 GB
EGAF00002545023 cram 11.8 GB
EGAF00002545024 cram 11.4 GB
EGAF00002545025 cram 9.9 GB
EGAF00002545026 cram 13.9 GB
EGAF00002545027 cram 17.3 GB
EGAF00002545028 cram 13.9 GB
EGAF00002545029 cram 17.4 GB
EGAF00002545030 cram 4.5 GB
EGAF00002545031 cram 4.8 GB
EGAF00002545032 cram 6.2 GB
EGAF00002545033 cram 6.3 GB
EGAF00002545034 cram 4.8 GB
EGAF00002545035 cram 6.1 GB
EGAF00002545036 cram 7.0 GB
EGAF00002545037 cram 4.7 GB
466 Files (2.7 TB)