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MutWP4: CRUK Grand Challenge Mutographs of Cancer: Gastric Organoids (2019-08-07)

The Mutographs project aims to advance our understanding of the causes of cancer through studies of mutational signatures. Led by Mike Stratton, together with Paul Brennan, Ludmil Alexandrov, Allan Balmain, David Phillips and Peter Campbell, this large-scale international research endeavour was awarded a Cancer Research UK Grand Challenge. Different patterns of somatic mutation are generated by the different environmental, lifestyle and genetic factors that cause cancer, many of them are still unknown. Within Mutographs, Kings College London will characterise the mutational signatures induced by putative human carcinogens in order to identify the origins of mutational signatures found in human cancers. To achieve this human organoid cell cultures will be exposed to a representative catalogue of known or suspected human carcinogens and mutagens and, using whole genome sequencing, the patterns of mutations induced by them will be determined. Somatic mutational signatures will be subsequently extracted by non-negative matrix factorisation methods and correlated with exposure data. Through an enhanced understanding of cancer aetiology, Mutographs unprecedented effort is anticipated to outline modifiable risk factors, lead to new approaches to prevent cancer, and provide opportunities to empower early detection, refine high-risk groups and contribute to further therapeutic development. . This dataset contains all the data available for this study on 2019-08-07.

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Studies are experimental investigations of a particular phenomenon, e.g., case-control studies on a particular trait or cancer research projects reporting matching cancer normal genomes from patients.

Study ID Study Title Study Type
EGAS00001003151 Cancer Genomics

This table displays only public information pertaining to the files in the dataset. If you wish to access this dataset, please submit a request. If you already have access to these data files, please consult the download documentation.

ID File Type Size Located in
EGAF00002444070 cram 18.0 GB
EGAF00002444071 cram 18.0 GB
EGAF00002444072 cram 18.3 GB
EGAF00002444073 cram 18.1 GB
EGAF00002444074 cram 7.8 GB
EGAF00002444075 cram 6.9 GB
EGAF00002444076 cram 7.4 GB
EGAF00002444077 cram 6.9 GB
EGAF00002444078 cram 7.1 GB
EGAF00002446806 cram 7.0 GB
EGAF00002446807 cram 6.6 GB
EGAF00002446808 cram 7.1 GB
EGAF00002446809 cram 6.6 GB
EGAF00002446810 cram 6.8 GB
EGAF00002446811 cram 6.7 GB
EGAF00002446812 cram 6.5 GB
EGAF00002446813 cram 6.9 GB
EGAF00002446814 cram 6.5 GB
EGAF00002446815 cram 6.3 GB
EGAF00002446816 cram 7.1 GB
EGAF00002446817 cram 6.8 GB
EGAF00002446818 cram 7.2 GB
EGAF00002446819 cram 6.8 GB
EGAF00002446820 cram 6.7 GB
EGAF00002446821 cram 7.0 GB
EGAF00002446822 cram 6.5 GB
EGAF00002446823 cram 7.1 GB
EGAF00002446824 cram 6.4 GB
EGAF00002446825 cram 6.7 GB
EGAF00002446826 cram 7.0 GB
EGAF00002446827 cram 6.6 GB
EGAF00002446828 cram 7.1 GB
EGAF00002446829 cram 6.7 GB
EGAF00002446830 cram 6.6 GB
EGAF00002446831 cram 6.9 GB
EGAF00002446832 cram 6.6 GB
EGAF00002446833 cram 7.0 GB
EGAF00002446834 cram 6.7 GB
EGAF00002446835 cram 6.6 GB
39 Files (311.6 GB)