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B-ALL bone marrow and CNS xenograft RNA sequencing

This dataset includes TruSeq paired-end, total RNA sequencing data from primary B-precursor acute lymphoblastic leukaemia (B-ALL) xenografts. It comprises 43 pairs of matched bone marrow (BM) and central nervous system (CNS) human leukaemia cells from individual immunodeficient mice. Xenografts were generated from 6 patients with B-ALL and include samples taken at diagnosis and relapse from 3 of 6 patients.

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Access to data generated by UHN is made available by completing the data access agreement for review by the data access committee and will be granted to qualified investigators for appropriate use.

DATA ACCESS AGREEMENT These terms and conditions govern access to the managed access datasets (details of which are set out in Appendix I) to which the User Institution has requested access. The User Institution agrees to be bound by these terms and conditions. Definitions Authorised Personnel: The individuals at the User Institution to whom the Data Access Committee (DAC) grants access to the Data. This includes the User, the individuals listed in Appendix II and any other individuals for whom the User Institution subsequently requests access to the Data. Details of the initial Authorised Personnel are set out in Appendix II. Data: The managed access datasets to which the User Institution has requested access. Data Producers: The Principal Investigator and the collaborators listed in Appendix I responsible for the development, organisation, and oversight of these Data. External Collaborator: A collaborator of the User, working for an institution other than the User Institution. Project: The project for which the User Institution has requested access to these Data. A description of the Project is set out in Appendix II. Publications: Includes, without limitation, articles published in print journals, electronic journals, reviews, books, posters and other written and verbal presentations of research. Research Participant: An individual whose data form part of these Data. Research Purposes: Shall mean research that is seeking to advance the understanding of genetics and genomics, including the treatment of disorders, and work on statistical methods that may be applied to such research. User: The principal investigator for the Project. User Institution(s): The Institution that has requested access to the Data. University Health Network: The University Health Network (UHN) is the largest clinical and research hospital in Canada. UHN is affiliated with the University of Toronto and is a member of the Toronto Academic Health Science Network. 1. The User Institution agrees to only use these Data for the purpose of the Project (described in Appendix II) and only for Research Purposes. The User Institution further agrees that it will only use these Data for Research Purposes which are within the limitations (if any) set out in Appendix I. 2. The User Institution agrees to preserve, at all times, the confidentiality of these Data. In particular, it undertakes not to use, or attempt to use these Data to compromise or otherwise infringe the confidentiality of information on Research Participants. Without prejudice to the generality of the foregoing, the User Institution agrees to use at least the measures set out in Appendix I to protect these Data. 3. The User Institution agrees to protect the confidentiality of Research Participants in any research papers or publications that they prepare by taking all reasonable care to limit the possibility of identification. 4. The User Institution agrees not to link or combine these Data to other information or archived data available in a way that could re-identify the Research Participants, even if access to that data has been formally granted to the User Institution or is freely available without restriction. 5. The User Institution agrees only to transfer or disclose these Data, in whole or part, or any material derived from these Data, to the Authorised Personnel. Should the User Institution wish to share these Data with an External Collaborator, the External Collaborator must complete a separate application for access to these Data. 6. The User Institution agrees that the Data Producers, and all other parties involved in the creation, funding or protection of these Data: a) make no warranty or representation, express or implied as to the accuracy, quality or comprehensiveness of these Data; b) exclude to the fullest extent permitted by law all liability for actions, claims, proceedings, demands, losses (including but not limited to loss of profit), costs, awards damages and payments made by the Recipient that may arise (whether directly or indirectly) in any way whatsoever from the Recipient’s use of these Data or from the unavailability of, or break in access to, these Data for whatever reason and; c) bear no responsibility for the further analysis or interpretation of these Data. 7. The User Institution agrees to follow the Fort Lauderdale Guidelines (http://www.wellcome.ac.uk/stellent/groups/corporatesite/@policy_communications/documents/web_document/wtd003207.pdf ) and the Toronto Statement (http://www.nature.com/nature/journal/v461/n7261/full/461168a.html). This includes but is not limited to recognising the contribution of the Data Producers and including a proper acknowledgement in all reports or publications resulting from the use of these Data. 8. The User Institution agrees to follow the Publication Policy in Appendix III. This includes respecting the moratorium period for the Data Producers to publish the first peer-reviewed report describing and analysing these Data. 9. The User Institution agrees not to make intellectual property claims on these Data and not to use intellectual property protection in ways that would prevent or block access to, or use of, any element of these Data, or conclusion drawn directly from these Data. 10. The User Institution can elect to perform further research that would add intellectual and resource capital to these data and decide to obtain intellectual property rights on these downstream discoveries. In this case, the User Institution agrees to implement licensing policies that will not obstruct further research and to follow the U.S. National Institutes of Health Best Practices for the Licensing of Genomic Inventions (2005) (https://www.icgc.org/files/daco/NIH_BestPracticesLicensingGenomicInventions_2005_en.pdf ) in conformity with the Organisation for Economic Co-operation and Development Guidelines for the Licensing of the Genetic Inventions (2006) (http://www.oecd.org/science/biotech/36198812.pdf ). 11. The User Institution agrees to destroy/discard the Data held, once it is no longer used for the Project, unless obliged to retain the data for archival purposes in conformity with audit or legal requirements. 12. The User Institution will notify the DAC within 30 days of any changes or departures of Authorised Personnel. 13. The User Institution will notify the DAC prior to any significant changes to the protocol for the Project. 14. The User Institution will notify the DAC as soon as it becomes aware of a breach of the terms or conditions of this agreement. 15. The DAC may terminate this agreement by written notice to the User Institution. If this agreement terminates for any reason, the User Institution will be required to destroy any Data held, including copies and backup copies. This clause does not prevent the User Institution from retaining these data for archival purpose in conformity with audit or legal requirements. 16. The User Institution accepts that it may be necessary for the Data Producers to alter the terms of this agreement from time to time. In the event that changes are required, the Data Producers or their appointed agent will contact the User Institution to inform it of the changes and the User Institution may elect to accept the changes or terminate the agreement. 17. If requested, the User Institution will allow data security and management documentation to be inspected to verify that it is complying with the terms of this agreement. 18. The User Institution agrees to distribute a copy of these terms to the Authorised Personnel. The User Institution will procure that the Authorised Personnel comply with the terms of this agreement. 19. This agreement (and any dispute, controversy, proceedings or claim of whatever nature arising out of this agreement or its formation) shall be construed, interpreted and governed by the laws of the province of Ontario and PHIPA. Agreed for User Institution Signature: Name: Title: Date: Principal Investigator I confirm that I have read and understood this Agreement. Signature: Name: Title: Date: Agreed for The Data Access Committee Signature: Name: Title: Date: APPENDIX I – DATASET DETAILS APPENDIX II ––PROJECT DETAILS APPENDIX III –– PUBLICATION POLICY

Studies are experimental investigations of a particular phenomenon, e.g., case-control studies on a particular trait or cancer research projects reporting matching cancer normal genomes from patients.

Study ID Study Title Study Type
EGAS00001005647 Other

This table displays only public information pertaining to the files in the dataset. If you wish to access this dataset, please submit a request. If you already have access to these data files, please consult the download documentation.

ID File Type Size Located in
EGAF00005494011 fastq.gz 1.6 GB
EGAF00005494012 fastq.gz 1.7 GB
EGAF00005494013 fastq.gz 1.6 GB
EGAF00005494014 fastq.gz 1.9 GB
EGAF00005494015 fastq.gz 1.6 GB
EGAF00005494016 fastq.gz 1.8 GB
EGAF00005494017 fastq.gz 1.6 GB
EGAF00005494018 fastq.gz 1.7 GB
EGAF00005494019 fastq.gz 1.6 GB
EGAF00005494020 fastq.gz 1.6 GB
EGAF00005494021 fastq.gz 1.7 GB
EGAF00005494022 fastq.gz 1.8 GB
EGAF00005494023 fastq.gz 1.5 GB
EGAF00005494024 fastq.gz 1.7 GB
EGAF00005494025 fastq.gz 1.4 GB
EGAF00005494026 fastq.gz 1.5 GB
EGAF00005494027 fastq.gz 1.4 GB
EGAF00005494028 fastq.gz 1.5 GB
EGAF00005494029 fastq.gz 1.9 GB
EGAF00005494030 fastq.gz 2.1 GB
EGAF00005494031 fastq.gz 1.9 GB
EGAF00005494032 fastq.gz 2.1 GB
EGAF00005494033 fastq.gz 1.5 GB
EGAF00005494034 fastq.gz 1.7 GB
EGAF00005494035 fastq.gz 1.6 GB
EGAF00005494036 fastq.gz 1.7 GB
EGAF00005494037 fastq.gz 1.7 GB
EGAF00005494038 fastq.gz 1.7 GB
EGAF00005494039 fastq.gz 1.7 GB
EGAF00005494040 fastq.gz 1.9 GB
EGAF00005494041 fastq.gz 1.7 GB
EGAF00005494042 fastq.gz 1.9 GB
EGAF00005494043 fastq.gz 2.0 GB
EGAF00005494044 fastq.gz 2.2 GB
EGAF00005494045 fastq.gz 1.6 GB
EGAF00005494046 fastq.gz 1.8 GB
EGAF00005494047 fastq.gz 2.2 GB
EGAF00005494048 fastq.gz 2.5 GB
EGAF00005494049 fastq.gz 4.0 GB
EGAF00005494050 fastq.gz 4.0 GB
EGAF00005494051 fastq.gz 1.3 GB
EGAF00005494052 fastq.gz 1.5 GB
EGAF00005494053 fastq.gz 1.9 GB
EGAF00005494054 fastq.gz 2.1 GB
EGAF00005494055 fastq.gz 1.6 GB
EGAF00005494056 fastq.gz 1.8 GB
EGAF00005494057 fastq.gz 2.0 GB
EGAF00005494058 fastq.gz 2.2 GB
EGAF00005494059 fastq.gz 1.8 GB
EGAF00005494060 fastq.gz 1.8 GB
EGAF00005494061 fastq.gz 1.5 GB
EGAF00005494062 fastq.gz 1.6 GB
EGAF00005494063 fastq.gz 1.8 GB
EGAF00005494064 fastq.gz 2.1 GB
EGAF00005494065 fastq.gz 1.6 GB
EGAF00005494066 fastq.gz 1.7 GB
EGAF00005494067 fastq.gz 1.5 GB
EGAF00005494068 fastq.gz 1.7 GB
EGAF00005494069 fastq.gz 1.4 GB
EGAF00005494070 fastq.gz 1.6 GB
EGAF00005494071 fastq.gz 1.5 GB
EGAF00005494072 fastq.gz 1.7 GB
EGAF00005494073 fastq.gz 3.4 GB
EGAF00005494074 fastq.gz 3.4 GB
EGAF00005494075 fastq.gz 1.9 GB
EGAF00005494076 fastq.gz 2.1 GB
EGAF00005494077 fastq.gz 1.6 GB
EGAF00005494078 fastq.gz 1.7 GB
EGAF00005494079 fastq.gz 3.5 GB
EGAF00005494080 fastq.gz 3.5 GB
EGAF00005494081 fastq.gz 2.7 GB
EGAF00005494082 fastq.gz 2.7 GB
EGAF00005494083 fastq.gz 1.8 GB
EGAF00005494084 fastq.gz 2.0 GB
EGAF00005494085 fastq.gz 1.8 GB
EGAF00005494086 fastq.gz 2.0 GB
EGAF00005494087 fastq.gz 1.9 GB
EGAF00005494088 fastq.gz 2.1 GB
EGAF00005494089 fastq.gz 1.8 GB
EGAF00005494090 fastq.gz 2.0 GB
EGAF00005494091 fastq.gz 1.6 GB
EGAF00005494092 fastq.gz 1.8 GB
EGAF00005494093 fastq.gz 1.8 GB
EGAF00005494094 fastq.gz 2.0 GB
EGAF00005494095 fastq.gz 1.7 GB
EGAF00005494096 fastq.gz 1.9 GB
EGAF00005494097 fastq.gz 1.6 GB
EGAF00005494098 fastq.gz 1.8 GB
EGAF00005494099 fastq.gz 1.5 GB
EGAF00005494100 fastq.gz 1.6 GB
EGAF00005494101 fastq.gz 1.4 GB
EGAF00005494102 fastq.gz 1.6 GB
EGAF00005494103 fastq.gz 1.4 GB
EGAF00005494104 fastq.gz 1.6 GB
EGAF00005494105 fastq.gz 1.5 GB
EGAF00005494106 fastq.gz 1.7 GB
EGAF00005494107 fastq.gz 1.5 GB
EGAF00005494108 fastq.gz 1.6 GB
EGAF00005494109 fastq.gz 1.7 GB
EGAF00005494110 fastq.gz 2.0 GB
EGAF00005494111 fastq.gz 1.5 GB
EGAF00005494112 fastq.gz 1.6 GB
EGAF00005494113 fastq.gz 1.8 GB
EGAF00005494114 fastq.gz 1.9 GB
EGAF00005494115 fastq.gz 1.7 GB
EGAF00005494116 fastq.gz 1.9 GB
EGAF00005494117 fastq.gz 1.6 GB
EGAF00005494118 fastq.gz 1.8 GB
EGAF00005494119 fastq.gz 1.9 GB
EGAF00005494120 fastq.gz 2.0 GB
EGAF00005494121 fastq.gz 1.7 GB
EGAF00005494122 fastq.gz 1.9 GB
EGAF00005494123 fastq.gz 2.0 GB
EGAF00005494124 fastq.gz 2.2 GB
EGAF00005494125 fastq.gz 1.8 GB
EGAF00005494126 fastq.gz 2.0 GB
EGAF00005494127 fastq.gz 1.7 GB
EGAF00005494128 fastq.gz 1.9 GB
EGAF00005494129 fastq.gz 1.5 GB
EGAF00005494130 fastq.gz 1.6 GB
EGAF00005494131 fastq.gz 1.9 GB
EGAF00005494132 fastq.gz 2.1 GB
EGAF00005494133 fastq.gz 1.8 GB
EGAF00005494134 fastq.gz 2.0 GB
EGAF00005494135 fastq.gz 1.6 GB
EGAF00005494136 fastq.gz 1.8 GB
EGAF00005494137 fastq.gz 1.8 GB
EGAF00005494138 fastq.gz 2.0 GB
EGAF00005494139 fastq.gz 1.8 GB
EGAF00005494140 fastq.gz 2.0 GB
EGAF00005494141 fastq.gz 1.6 GB
EGAF00005494142 fastq.gz 1.8 GB
EGAF00005494143 fastq.gz 3.3 GB
EGAF00005494144 fastq.gz 3.4 GB
EGAF00005494145 fastq.gz 2.0 GB
EGAF00005494146 fastq.gz 2.2 GB
EGAF00005494147 fastq.gz 1.8 GB
EGAF00005494148 fastq.gz 2.1 GB
EGAF00005494149 fastq.gz 1.9 GB
EGAF00005494150 fastq.gz 2.0 GB
EGAF00005494151 fastq.gz 2.3 GB
EGAF00005494152 fastq.gz 2.6 GB
EGAF00005494153 fastq.gz 1.5 GB
EGAF00005494154 fastq.gz 1.7 GB
EGAF00005494155 fastq.gz 1.7 GB
EGAF00005494156 fastq.gz 1.9 GB
EGAF00005494157 fastq.gz 1.8 GB
EGAF00005494158 fastq.gz 1.9 GB
EGAF00005494159 fastq.gz 1.8 GB
EGAF00005494160 fastq.gz 2.0 GB
EGAF00005494161 fastq.gz 1.9 GB
EGAF00005494162 fastq.gz 2.2 GB
EGAF00005494163 fastq.gz 3.0 GB
EGAF00005494164 fastq.gz 3.1 GB
EGAF00005494165 fastq.gz 1.7 GB
EGAF00005494166 fastq.gz 1.9 GB
EGAF00005494167 fastq.gz 1.7 GB
EGAF00005494168 fastq.gz 1.9 GB
EGAF00005494169 fastq.gz 1.6 GB
EGAF00005494170 fastq.gz 1.8 GB
EGAF00005494171 fastq.gz 1.7 GB
EGAF00005494172 fastq.gz 1.8 GB
EGAF00005494173 fastq.gz 2.0 GB
EGAF00005494174 fastq.gz 2.2 GB
EGAF00005494175 fastq.gz 1.5 GB
EGAF00005494176 fastq.gz 1.8 GB
EGAF00005494177 fastq.gz 1.7 GB
EGAF00005494178 fastq.gz 1.9 GB
EGAF00005494179 fastq.gz 1.7 GB
EGAF00005494180 fastq.gz 1.9 GB
EGAF00005494181 fastq.gz 1.7 GB
EGAF00005494182 fastq.gz 1.8 GB
172 Files (326.1 GB)