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Postmortem Single Nuclei and Bulk RNA-seq data of the Motor Cortex and Spinal Cord for Healthy, C9ALS and sALS Patients

This dataset contains both snRNA-seq and bulk RNA-seq data from 19 different patients, comprising of 9 healthy controls (4 Spinal Cord, 5 Motor Cortex) as well as 5 C9ALS patients and 5 sporadic ALS patients, each with paired data from the spinal cord and motor cortex. For the snRNA-seq data, fastq files containing the raw reads are provided, many of these samples were pooled for sequencing and subsequently require demultiplexing using SNPs using a tool such as freemuxlet. The paired bulk RNA-seq data (raw fastq files) can be used to acquire the ground truth per patient - a list of pooled samples can be found in map.txt. snRNA-seq data was produced using the 10X Genomics 3' v3 kit and bulk RNA-seq was produced using the Illumina TruSeq v2 kit.

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VIB Policy for Data Access and Data Transfer

Applicability This policy applies to the access to and transfer of VIB research datasets that contain non-anonymous Personal Data which are subject to the provisions of the General Data Protection Regulation (EU) 2016/679. Access/transfer conditions - The access/transfer is subject to approval by the VIB Data Access Committee. - The proposed research purpose should not be incompatible with the primary research purpose for which the data were originally generated. - The Recipient shall have in place adequate safeguards for the protection of Personal Data. - Access is subject to a Data Transfer/Access Agreement which will be managed by VIB Innovation & Business. - The Data Transfer/Access will be limited to the Data that are necessary for the proposed research. Access/transfer procedure - Requests to access or obtain non-anonymous datasets should be submitted to the responsible corresponding author that has uploaded the dataset into the repository, and with a copy to dac@vib.be. - The request should contain the following information: - Name, affiliation (legal entity) and contact information of the requesting recipient party. - Reference to the specific dataset(s) for which access or transfer is requested. - Description of the research purpose for which the data will be used. - The VIB Data Access Committee takes decisions to approve access/transfer within 14 days upon receipt of the request. - Data access will be given / Data will be transferred after completion of the Data Transfer/Access Agreement.

Studies are experimental investigations of a particular phenomenon, e.g., case-control studies on a particular trait or cancer research projects reporting matching cancer normal genomes from patients.

Study ID Study Title Study Type
EGAS00001006711 Other

This table displays only public information pertaining to the files in the dataset. If you wish to access this dataset, please submit a request. If you already have access to these data files, please consult the download documentation.

ID File Type Size Located in
EGAF00007514206 fastq.gz 11.2 GB
EGAF00007514207 fastq.gz 26.5 GB
EGAF00007514208 fastq.gz 5.1 GB
EGAF00007514209 fastq.gz 11.6 GB
EGAF00007514210 fastq.gz 5.2 GB
EGAF00007514211 fastq.gz 11.9 GB
EGAF00007514212 fastq.gz 5.9 GB
EGAF00007514213 fastq.gz 13.7 GB
EGAF00007514214 fastq.gz 6.4 GB
EGAF00007514215 fastq.gz 14.7 GB
EGAF00007514216 fastq.gz 4.5 GB
EGAF00007514217 fastq.gz 10.8 GB
EGAF00007514218 fastq.gz 13.4 GB
EGAF00007514219 fastq.gz 31.7 GB
EGAF00007514220 fastq.gz 4.6 GB
EGAF00007514221 fastq.gz 11.1 GB
EGAF00007514222 fastq.gz 7.7 GB
EGAF00007514223 fastq.gz 17.9 GB
EGAF00007514224 fastq.gz 7.2 GB
EGAF00007514225 fastq.gz 16.7 GB
EGAF00007514226 fastq.gz 7.6 GB
EGAF00007514227 fastq.gz 17.5 GB
EGAF00007514228 fastq.gz 7.8 GB
EGAF00007514229 fastq.gz 18.3 GB
EGAF00007514230 fastq.gz 7.4 GB
EGAF00007514231 fastq.gz 17.3 GB
EGAF00007514232 fastq.gz 3.4 GB
EGAF00007514233 fastq.gz 7.7 GB
EGAF00007514234 fastq.gz 5.2 GB
EGAF00007514235 fastq.gz 11.9 GB
EGAF00007514236 fastq.gz 1.2 GB
EGAF00007514237 fastq.gz 1.1 GB
EGAF00007514238 fastq.gz 1.1 GB
EGAF00007514239 fastq.gz 1.2 GB
EGAF00007514240 fastq.gz 1.2 GB
EGAF00007514241 fastq.gz 1.2 GB
EGAF00007514242 fastq.gz 1.1 GB
EGAF00007514243 fastq.gz 893.2 MB
EGAF00007514244 fastq.gz 1.1 GB
EGAF00007514245 fastq.gz 1.0 GB
EGAF00007514246 fastq.gz 1.2 GB
EGAF00007514247 fastq.gz 914.6 MB
EGAF00007514248 fastq.gz 875.6 MB
EGAF00007514249 fastq.gz 931.8 MB
EGAF00007514250 fastq.gz 1.2 GB
EGAF00007514251 fastq.gz 1.1 GB
EGAF00007514252 fastq.gz 1.0 GB
EGAF00007514253 fastq.gz 935.3 MB
EGAF00007514254 fastq.gz 1.1 GB
EGAF00007514255 fastq.gz 3.8 GB
EGAF00007514256 fastq.gz 8.7 GB
EGAF00007514257 fastq.gz 3.2 GB
EGAF00007514258 fastq.gz 7.5 GB
EGAF00007514259 fastq.gz 3.5 GB
EGAF00007514260 fastq.gz 8.2 GB
EGAF00007514261 fastq.gz 3.0 GB
EGAF00007514262 fastq.gz 6.9 GB
EGAF00007514263 fastq.gz 1.9 GB
EGAF00007514264 fastq.gz 4.3 GB
EGAF00007514265 fastq.gz 4.2 GB
EGAF00007514266 fastq.gz 9.4 GB
EGAF00007514267 txt 2.2 kB
62 Files (426.9 GB)