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Single cell chromatin accessibility profiles from myelofibrosis patients

To explore how JAK2V617F disrupts cell-fate and the regulatory chromatin landscape of HSCs, we applied GoT-ChA to CD34+ sorted progenitor cells from 21 human primary samples, comprising 18 patients with JAK2V617F-mutated MF (no additional mutations, except for Pt-08), who either had no treatment (n = 12; including three longitudinal samples from a PV patient who progressed to MF) or who were treated with ruxolitinib (n = 6), a JAK1/2 inhibitor. We included a JAK2V617F CH sample (Pt-19) to explore early epigenetic changes, before the onset of overt hematological abnormality.

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Details for GoT-ChA data access

DATA ACCESS AGREEMENT These terms and conditions govern access to the managed access datasets (details of which are set out in Appendix I) to which the User Institution has requested access. The User Institution agrees to be bound by these terms and conditions. Definitions Authorized Personnel: The individuals at the User Institution to whom the Single-Cell Chromatin Accessibility Data Team Access Committee grants access to the Data. This includes the User, the individuals listed in Appendix II and any other individuals for whom the User Institution subsequently requests access to the Data. Details of the initial Authorized Personnel are set out in Appendix II. Data: The managed access datasets to which the User Institution has requested access. Data Producers: Single-Cell Chromatin Accessibility Data Team Access Committee and the collaborators listed in Appendix I responsible for the development, organization, and oversight of these Data. External Collaborator: A collaborator of the User, working for an institution other than the User Institution. Project: The project for which the User Institution has requested access to these Data. A description of the Project is set out in Appendix II. Publications: Includes, without limitation, articles published in print journals, electronic journals, reviews, books, posters and other written and verbal presentations of research. Research Participant: An individual whose data form part of these Data. Research Purposes: Shall mean research that is seeking to advance the understanding of genetics and genomics, including the treatment of disorders, and work on statistical methods that may be applied to such research. User: The principal investigator for the Project. User Institution(s): The Institution that has requested access to the Data. Single-Cell Chromatin Accessibility Data Team Access Committee: 413 East 69th Street, Room 1428 New York, NY 10021

Studies are experimental investigations of a particular phenomenon, e.g., case-control studies on a particular trait or cancer research projects reporting matching cancer normal genomes from patients.

Study ID Study Title Study Type
EGAS50000000164 Epigenetics
  • Added two more runs for sample Pt-02 and the corresponding Experiment and Analysis
  • Dataset Released

This table displays only public information pertaining to the files in the dataset. If you wish to access this dataset, please submit a request. If you already have access to these data files, please consult the download documentation.

ID File Type Size Located in
EGAF50000080478 bam 21.9 GB
EGAF50000080479 bam 8.9 GB
EGAF50000080480 bam 29.7 GB
EGAF50000080481 bam 27.9 GB
EGAF50000080482 bam 5.3 GB
EGAF50000080483 bam 7.7 GB
EGAF50000080484 bam 34.0 GB
EGAF50000080485 bam 26.0 GB
EGAF50000080486 bam 31.2 GB
EGAF50000080487 bam 27.2 GB
EGAF50000080488 bam 34.4 GB
EGAF50000080489 bam 33.1 GB
EGAF50000080490 bam 38.2 GB
EGAF50000080491 bam 12.4 GB
EGAF50000080492 bam 39.3 GB
EGAF50000080493 bam 15.2 GB
EGAF50000080494 bam 26.7 GB
EGAF50000080495 bam 25.0 GB
EGAF50000080496 bam 26.2 GB
EGAF50000080497 bam 25.8 GB
EGAF50000080498 bam 36.7 GB
EGAF50000080499 bam 35.8 GB
EGAF50000080500 bam 16.7 GB
EGAF50000080501 bam 12.2 GB
EGAF50000080502 bam 10.7 GB
EGAF50000080503 bam 17.1 GB
EGAF50000080504 bam 17.0 GB
EGAF50000080505 bam 39.2 GB
EGAF50000080506 bai 3.4 MB
EGAF50000080507 bai 5.0 MB
EGAF50000080508 bai 8.7 MB
EGAF50000080509 bai 3.5 MB
EGAF50000080510 bai 7.6 MB
EGAF50000080511 bai 5.6 MB
EGAF50000080512 bai 3.9 MB
EGAF50000080513 bai 5.3 MB
EGAF50000080514 bai 4.6 MB
EGAF50000080515 bai 5.6 MB
EGAF50000080516 bai 4.4 MB
EGAF50000080517 bai 3.3 MB
EGAF50000080518 bai 5.2 MB
EGAF50000080519 bai 8.7 MB
EGAF50000080520 bai 4.6 MB
EGAF50000080521 bai 7.9 MB
EGAF50000080522 bai 7.7 MB
EGAF50000080523 bai 4.0 MB
EGAF50000080524 bai 4.0 MB
EGAF50000080525 bai 3.2 MB
EGAF50000080526 bai 3.1 MB
EGAF50000080527 bai 5.2 MB
EGAF50000080528 bai 4.6 MB
EGAF50000080529 bai 4.0 MB
EGAF50000080530 bai 5.2 MB
EGAF50000080531 bai 6.9 MB
EGAF50000080532 bai 7.0 MB
EGAF50000080533 bai 4.3 MB
EGAF50000083622 bam 57.2 GB
EGAF50000083623 bam 35.0 GB
EGAF50000083624 bai 8.5 MB
EGAF50000083625 bai 16.5 MB
60 Files (774.1 GB)