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Pediatric HGG panel sequencing

Targeted glioma panel sequencing of pediatric hemispheric high-grade gliomas and diffuse midline gliomas. File type is paired-read fastq files (2 per sample). Sequencing was performed on Illumina NextSex instruments. Genes covered: TP53, H3F3A, HIST1H3B, HIST1H3C, IDH1, IDH2, KRAS, PIK3CA, TERT promoter, PTPN11, FGFR1/2/3, MYB, BRAF, MYBL1, EGFR, PDGFRA, MYCN, MYC, CDKN2A.

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Hospital for Sick Children Data Access Agreement

SickKids Data Access Agreement THE HOSPITAL FOR SICK CHILDREN ("SickKids") DATA ACCESS AGREEMENT (Access to Genomic/Proteomic Data) This agreement governs the terms on which access will be granted to the genotype data generated by the principal investigator, Dr. Cynthia Hawkins, and SickKids. In signing this agreement, the User (as defined below) is agreeing to be bound by the terms and conditions of access set out in this agreement. For the sake of clarity, the terms of access set out in this agreement apply both to the User and the User's Institution (as defined below). User Institution and User referred to within the agreement as "You" and "Your" shall be construed accordingly. Definitions: Hawkins/SickKids means Dr. Hawkins and The Hospital for Sick Children. Data means all and any published human expression or genomic/proteomic data obtained from Hawkins/SickKids Data Subject(s) means a person, who has been informed of the purpose for which the Data is held and has given his/her informed consent thereto, as approved by the appropriate Research Ethics Board ("REB") or consistent with an REB waiver of consent. User means a qualified researcher whose User Institution has previously completed this Data Access Agreement and has received acknowledgement of its acceptance. Publications means, without limitation, articles published in print journals, electronic journals, reviews, books, posters and other written and verbal presentations of research. User Institution means the academic organisation at which the User is employed, affiliated or enrolled. Terms and Conditions: In signing this Agreement: 1. You agree to use the Data only for the advancement of medical research, according to the consent obtained from Data Subject(s). 2. You agree that You are a laboratory head, principal investigator or departmental chair and take responsibility for the distribution restrictions defined in Section 4 of this Agreement, and use of and protection of the Data by your laboratory. 3. You agree not to use the data from Hawkins/SickKids or any part thereof for the creation of products for sale or for any commercial purpose. 4. You agree to preserve, at all times, the confidentiality of information and Data pertaining to Data Subjects. In particular, you undertake not to use, or attempt to use the Data to compromise or otherwise infringe the confidentiality of information on Data Subjects and their right to privacy. 5. You agree not to attempt to link the Data provided under this agreement to other information or archive Data available for the data sets provided, even if access to that Data has been formally granted to you, or it is freely available without restriction, without specific permission being sought from Dr. Hawkins or a designate of Dr. Hawkins, as applicable. 6. You agree not to transfer or disclose the Data, in whole or part, or any identifiable material derived from the Data, to others, including other investigators and laboratories in your Institution, except as necessary for data/safety monitoring or programme management. Should You wish to share the Data with a collaborator within or outside the same Institution, the third party must make a separate application to access the Data. 7. You agree to use the Data for the approved purpose and project described in your application; use of the Data for a new purpose or project will require a new application and approval. 8. You agree that you have the computation infrastructure and expertise to analyse the Data. 9. You agree that the Data are made available for one (1) year. You agree to destroy the Data after on (1) year. You must re-apply to access the Data after this period. 10. You accept that Data will be reissued from time to time, with suitable versioning. If the reissue is at the request of sample donors and/or other ethical scrutiny, You will destroy earlier versions of the Data. 11. You agree to abide by the terms outlined in the SickKids 'Publications Policy' as set out in Schedule 1. By signing this Agreement, You agree not to use the Data generated for each tumour type for any Publication for a minimum of nine (9) months after public release of the Data by Dr. Hawkins or until Publication of the Data by Dr. Hawkins, whichever occurs first. 12. You accept that the genomic/proteomic data provided in this initial nine (9) month period following disposition is provided "as is" without associated phenotype data or data verifying and/or validating the presence of putative genetic alterations. 13. You agree to acknowledge in any work based in whole or part on the Data, the published paper from which the Data derives, the version of the Data, and the role of Hawkins/SickKids and the relevant primary collectors and their funders. Suitable wording is provided in the Publications Policy given in Schedule 1. 14. You accept that Hawkins/SickKids, the original Data creators, depositors or copyright holders, or the funders of the Data or any part of the Data supplied: a) bear no legal responsibility for the accuracy or comprehensiveness of the Data; and b) accept no liability for indirect, consequential, or incidental, damages or losses arising from use of the Data, or from the unavailability of, or break in access to, the Data for whatever reason. 15. You understand and acknowledge that the Data is protected by copyright and other intellectual property rights, and that duplication, except as reasonably required to carry out Your research with the Data, or sale of all or part of the Data on any media is not permitted. 16. You recognise that nothing in this Agreement shall operate to transfer to the User or User Institution any intellectual property rights relating to the Data. The User and/or User Institution has the right to develop intellectual property based on comparisons with their own data. 17. You accept that this Agreement will terminate immediately upon any breach of this Agreement by You and You will be required to destroy any Data held. 18. You accept that it may be necessary for Hawkins/SickKids or its appointed agent to alter the terms of this agreement from time to time in order to address new concerns. In this event, Hawkins/SickKids or its appointed agent will contact You to inform You of any changes and You agree that Your continued use of the Data shall be dependent on the parties entering into a new version of the Agreement. 19. You agree that you will submit a report to Hawkins/SickKids, if requested, on completion of the agreed purpose. Hawkins/SickKids agree to treat the report and all information, data, results, and conclusions contained within such report as confidential information belonging to the User Institution. You further agree to provide a copy of any Publications arising from the use of the Data to Hawkins/SickKids withing thirty (30) days of its publication. 20. You accept that the Data is protected by and subject to international laws, including but not limited to the UK Data Protection Act 1998, the Ontario Personal Health Information Protection Act, 2004 and the Canadian Personal Information and Electronic Documents Act, 2000, and that You are responsible for ensuring compliance with any such applicable law. Dr. Hawkins, and SickKids reserves the right to request and inspect data security and management documentation to ensure the adequacy of data protection measures in countries that have no national laws comparable to that which pertain in the EAA. 21. This agreement shall be construed, interpreted and governed by the laws of the Province of Ontario and federal laws of Canada applicable thereto and shall be subject to the non-exclusive jurisdiction of the Ontario courts. SCHEDULE 1. Publications Policy The Hospital for Sick Children is recognized as one of the world's foremost paediatric health-care institutions and is Canada's leading centre dedicated to advancing children's health through the integration of patient care, research and education. The Hawkins lab is focused on the cellular and molecular mechanisms that underlie tumour development and maintenance in central nervous system diffuse midline glioma/diffuse intrinsic pontine gliomas, the main cause of brain tumour death in children. Current projects involve use of high resolution genomic/proteomic tools such as whole genome sequencing, whole exome sequencing, SNP microarrays, epigenetic and gene expression data, high-resolution mass spectrometry data, and data integration, as well as use of the data generated to answer important methodological and biological questions. Hawkins/SickKids anticipates that Data generated from the project will be used by others, such as required for developing new analytical methods, validation of results, and the identification of additional genetic variations to assist in understanding patterns of polymorphism and in guiding selection of markers to map genes involved in specific diseases. Authors who use Data from the project must acknowledge Hawkins/SickKids using the following wording “This study makes use of data generated by the Principal Investigator Dr. Cynthia Hawkins and the Hospital for Sick Children" and cite the relevant primary publication by the aforementioned. Users should note that Hawkins/SickKids bears no responsibility for the further analysis or interpretation of these Data, over and above that published by the Hawkins/SickKids. For and on behalf of User: Name ofApplicant(s): Signature ofApplicant(s): Date: For and on behalf of User Institution: Signature of Institutional or Administrative Authority: Print name: User Institution: Date: WHEN SUBMITTING THIS DOCUMENT, PLEASE INCLUDE ALL PAGES OF THE AGREEMENT WITH THIS SIGNATURE PAGE TOGETHER WITH THE SICKKIDS APPLICATION FORM ATTACHED HERETO AS APPENDIX 1. APPENDIX 1 Arthur and Sonia Labatt Brain Tumour Research Centre Application for Access to Hawkins/Sickkids Data Name of applicant and co-applicant(s), including affiliations and contact details. Please ensure that a full postal and email address is included for each applicant. PhD student applicants must include their supervisors as a co-applicant and provide their full contact details. Title of Project In less than 30 words. Data Requested Please indicate which type of data you require. Research Question Please provide a clear description of the project and its specific aims in no more than 750 words. This should include specific details of what you plan to do with the data and include key references. Feasibilty Please describe fully your experience and expertise, and that of your collaborators, and how this will be applied to the proposed study. A publication list MUST be provided for the applicant, co-applicants and PhD supervisors where PhD students have applied. The committee needs assurance of competence in handling datasets of this size and nature. I have read and agree to abide by the terms and conditions outlined in the Data Access Agreement and the Publication Policy WTCCC DAA ver18, Jun 2010.

Studies are experimental investigations of a particular phenomenon, e.g., case-control studies on a particular trait or cancer research projects reporting matching cancer normal genomes from patients.

Study ID Study Title Study Type
EGAS50000000221 Exome Sequencing

This table displays only public information pertaining to the files in the dataset. If you wish to access this dataset, please submit a request. If you already have access to these data files, please consult the download documentation.

ID File Type Size Located in
EGAF50000088001 fq.gz 422.0 MB
EGAF50000088002 fq.gz 431.6 MB
EGAF50000088003 fq.gz 238.2 MB
EGAF50000088004 fq.gz 243.7 MB
EGAF50000088005 fq.gz 79.7 MB
EGAF50000088006 fq.gz 39.0 MB
EGAF50000088007 fq.gz 360.8 MB
EGAF50000088008 fq.gz 203.5 MB
EGAF50000088009 fq.gz 208.9 MB
EGAF50000088010 fq.gz 174.3 MB
EGAF50000088011 fq.gz 181.0 MB
EGAF50000088012 fq.gz 107.6 MB
EGAF50000088013 fq.gz 114.5 MB
EGAF50000088014 fq.gz 122.8 MB
EGAF50000088015 fq.gz 104.4 MB
EGAF50000088016 fq.gz 55.1 MB
EGAF50000088017 fq.gz 211.1 MB
EGAF50000088018 fq.gz 219.1 MB
EGAF50000088019 fq.gz 112.0 MB
EGAF50000088020 fq.gz 116.1 MB
EGAF50000088021 fq.gz 181.6 MB
EGAF50000088022 fq.gz 184.2 MB
EGAF50000088023 fq.gz 97.8 MB
EGAF50000088024 fq.gz 285.1 MB
EGAF50000088025 fq.gz 469.3 MB
EGAF50000088026 fq.gz 307.9 MB
EGAF50000088027 fq.gz 112.7 MB
EGAF50000088028 fq.gz 114.6 MB
EGAF50000088029 fq.gz 147.0 MB
EGAF50000088030 fq.gz 128.7 MB
EGAF50000088031 fq.gz 340.5 MB
EGAF50000088032 fq.gz 368.6 MB
EGAF50000088033 fq.gz 293.8 MB
EGAF50000088034 fq.gz 172.7 MB
EGAF50000088035 fq.gz 175.1 MB
EGAF50000088036 fq.gz 128.0 MB
EGAF50000088037 fq.gz 270.2 MB
EGAF50000088038 fq.gz 276.7 MB
EGAF50000088039 fq.gz 326.7 MB
EGAF50000088040 fq.gz 314.7 MB
EGAF50000088041 fq.gz 321.8 MB
EGAF50000088042 fq.gz 458.1 MB
EGAF50000088043 fq.gz 299.0 MB
EGAF50000088044 fq.gz 212.0 MB
EGAF50000088045 fq.gz 213.7 MB
EGAF50000088046 fq.gz 144.2 MB
EGAF50000088047 fq.gz 146.8 MB
EGAF50000088048 fq.gz 738.0 MB
EGAF50000088049 fq.gz 754.8 MB
EGAF50000088050 fq.gz 157.8 MB
EGAF50000088051 fq.gz 169.6 MB
EGAF50000088052 fq.gz 173.3 MB
EGAF50000088053 fq.gz 421.4 MB
EGAF50000088054 fq.gz 119.9 MB
EGAF50000088055 fq.gz 220.0 MB
EGAF50000088056 fq.gz 125.0 MB
EGAF50000088057 fq.gz 212.9 MB
EGAF50000088058 fq.gz 221.0 MB
EGAF50000088059 fq.gz 87.0 MB
EGAF50000088060 fq.gz 437.8 MB
EGAF50000088061 fq.gz 789.5 MB
EGAF50000088062 fq.gz 122.4 MB
EGAF50000088063 fq.gz 87.8 MB
EGAF50000088064 fq.gz 91.3 MB
EGAF50000088065 fq.gz 111.9 MB
EGAF50000088066 fq.gz 124.2 MB
EGAF50000088067 fq.gz 110.9 MB
EGAF50000088068 fq.gz 65.7 MB
EGAF50000088069 fq.gz 769.3 MB
EGAF50000088070 fq.gz 139.0 MB
EGAF50000088071 fq.gz 120.7 MB
EGAF50000088072 fq.gz 126.5 MB
EGAF50000088073 fq.gz 624.4 MB
EGAF50000088074 fq.gz 515.6 kB
EGAF50000088075 fq.gz 67.4 MB
EGAF50000088076 fq.gz 124.8 MB
EGAF50000088077 fq.gz 128.5 MB
EGAF50000088078 fq.gz 45.4 MB
EGAF50000088079 fq.gz 253.5 MB
EGAF50000088080 fq.gz 125.3 MB
EGAF50000088081 fq.gz 154.7 MB
EGAF50000088082 fq.gz 219.8 MB
EGAF50000088083 fq.gz 224.5 MB
EGAF50000088084 fq.gz 154.0 MB
EGAF50000088085 fq.gz 99.8 MB
EGAF50000088086 fq.gz 158.9 MB
EGAF50000088087 fq.gz 162.2 MB
EGAF50000088088 fq.gz 313.7 MB
EGAF50000088089 fq.gz 325.6 MB
EGAF50000088090 fq.gz 137.1 MB
EGAF50000088091 fq.gz 138.7 MB
EGAF50000088092 fq.gz 130.2 MB
EGAF50000088093 fq.gz 124.2 MB
EGAF50000088094 fq.gz 130.0 MB
EGAF50000088095 fq.gz 165.7 MB
EGAF50000088096 fq.gz 105.2 MB
EGAF50000088097 fq.gz 156.1 MB
EGAF50000088098 fq.gz 158.5 MB
EGAF50000088099 fq.gz 147.6 MB
EGAF50000088100 fq.gz 149.8 MB
EGAF50000088101 fq.gz 59.7 MB
EGAF50000088102 fq.gz 61.5 MB
EGAF50000088103 fq.gz 84.0 MB
EGAF50000088104 fq.gz 85.8 MB
EGAF50000088105 fq.gz 151.7 MB
EGAF50000088106 fq.gz 155.7 MB
EGAF50000088107 fq.gz 103.0 MB
EGAF50000088108 fq.gz 110.7 MB
EGAF50000088109 fq.gz 113.3 MB
EGAF50000088110 fq.gz 203.8 MB
EGAF50000088111 fq.gz 253.2 MB
EGAF50000088112 fq.gz 259.7 MB
EGAF50000088113 fq.gz 188.4 MB
EGAF50000088114 fq.gz 110.3 MB
EGAF50000088115 fq.gz 132.8 MB
EGAF50000088116 fq.gz 140.2 MB
EGAF50000088117 fq.gz 189.0 MB
EGAF50000088118 fq.gz 128.5 MB
EGAF50000088119 fq.gz 134.1 MB
EGAF50000088120 fq.gz 142.5 MB
EGAF50000088121 fq.gz 145.7 MB
EGAF50000088122 fq.gz 263.0 MB
EGAF50000088123 fq.gz 270.2 MB
EGAF50000088124 fq.gz 287.5 MB
EGAF50000088125 fq.gz 293.9 MB
EGAF50000088126 fq.gz 211.0 MB
EGAF50000088127 fq.gz 214.4 MB
EGAF50000088128 fq.gz 483.4 MB
EGAF50000088129 fq.gz 208.5 MB
EGAF50000088130 fq.gz 170.6 MB
EGAF50000088131 fq.gz 154.3 MB
EGAF50000088132 fq.gz 183.9 MB
EGAF50000088133 fq.gz 68.8 MB
EGAF50000088134 fq.gz 120.5 MB
EGAF50000088135 fq.gz 500.2 MB
EGAF50000088136 fq.gz 503.7 MB
EGAF50000088137 fq.gz 720.9 MB
EGAF50000088138 fq.gz 730.1 MB
EGAF50000088139 fq.gz 663.6 MB
EGAF50000088140 fq.gz 678.5 MB
EGAF50000088141 fq.gz 847.2 MB
EGAF50000088142 fq.gz 861.5 MB
EGAF50000088143 fq.gz 490.7 MB
EGAF50000088144 fq.gz 205.2 MB
EGAF50000088145 fq.gz 47.1 MB
EGAF50000088146 fq.gz 209.7 MB
EGAF50000088147 fq.gz 136.8 MB
EGAF50000088148 fq.gz 143.8 MB
EGAF50000088149 fq.gz 48.5 MB
EGAF50000088150 fq.gz 49.1 MB
EGAF50000088151 fq.gz 201.8 MB
EGAF50000088152 fq.gz 206.4 MB
EGAF50000088153 fq.gz 137.1 MB
EGAF50000088154 fq.gz 140.1 MB
EGAF50000088155 fq.gz 155.5 MB
EGAF50000088156 fq.gz 116.9 MB
EGAF50000088157 fq.gz 119.6 MB
EGAF50000088158 fq.gz 100.9 MB
EGAF50000088159 fq.gz 103.0 MB
EGAF50000088160 fq.gz 102.9 MB
EGAF50000088161 fq.gz 116.9 MB
EGAF50000088162 fq.gz 120.7 MB
EGAF50000088163 fq.gz 80.0 MB
EGAF50000088164 fq.gz 81.3 MB
EGAF50000088165 fq.gz 66.7 MB
EGAF50000088166 fq.gz 67.8 MB
EGAF50000088167 fq.gz 118.0 MB
EGAF50000088168 fq.gz 120.6 MB
EGAF50000088169 fq.gz 122.3 MB
EGAF50000088170 fq.gz 90.9 MB
EGAF50000088171 fq.gz 93.4 MB
EGAF50000088172 fq.gz 151.1 MB
EGAF50000088173 fq.gz 117.2 MB
EGAF50000088174 fq.gz 224.5 MB
EGAF50000088175 fq.gz 21.0 MB
EGAF50000088176 fq.gz 21.3 MB
EGAF50000088177 fq.gz 89.6 MB
EGAF50000088178 fq.gz 106.4 MB
EGAF50000088179 fq.gz 110.4 MB
EGAF50000088180 fq.gz 133.5 MB
EGAF50000088181 fq.gz 136.1 MB
EGAF50000088182 fq.gz 117.6 MB
EGAF50000088183 fq.gz 121.2 MB
EGAF50000088184 fq.gz 123.8 MB
EGAF50000088185 fq.gz 126.3 MB
EGAF50000088186 fq.gz 83.2 MB
EGAF50000088187 fq.gz 84.7 MB
EGAF50000088188 fq.gz 107.9 MB
EGAF50000088189 fq.gz 112.8 MB
EGAF50000088190 fq.gz 110.3 MB
EGAF50000088191 fq.gz 111.6 MB
EGAF50000088192 fq.gz 159.2 MB
EGAF50000088193 fq.gz 94.3 MB
EGAF50000088194 fq.gz 96.0 MB
EGAF50000088195 fq.gz 130.4 MB
EGAF50000088196 fq.gz 134.2 MB
EGAF50000088197 fq.gz 93.8 MB
EGAF50000088198 fq.gz 97.8 MB
EGAF50000088199 fq.gz 187.0 MB
EGAF50000088200 fq.gz 134.3 MB
EGAF50000088201 fq.gz 126.6 MB
EGAF50000088202 fq.gz 170.0 MB
EGAF50000088203 fq.gz 173.2 MB
EGAF50000088204 fq.gz 102.2 MB
EGAF50000088205 fq.gz 26.6 MB
EGAF50000088206 fq.gz 27.8 MB
EGAF50000088207 fq.gz 125.8 MB
EGAF50000088208 fq.gz 131.8 MB
EGAF50000088209 fq.gz 113.3 MB
EGAF50000088210 fq.gz 128.7 MB
EGAF50000088211 fq.gz 130.7 MB
EGAF50000088212 fq.gz 94.2 MB
EGAF50000088213 fq.gz 95.9 MB
EGAF50000088214 fq.gz 79.3 MB
EGAF50000088215 fq.gz 81.1 MB
EGAF50000088216 fq.gz 57.5 MB
EGAF50000088217 fq.gz 59.2 MB
EGAF50000088218 fq.gz 112.3 MB
EGAF50000088219 fq.gz 115.4 MB
EGAF50000088220 fq.gz 81.2 MB
EGAF50000088221 fq.gz 106.4 MB
EGAF50000088222 fq.gz 108.0 MB
EGAF50000088223 fq.gz 58.3 MB
EGAF50000088224 fq.gz 60.1 MB
EGAF50000088225 fq.gz 71.5 MB
EGAF50000088226 fq.gz 41.9 MB
EGAF50000088227 fq.gz 43.5 MB
EGAF50000088228 fq.gz 40.8 MB
EGAF50000088229 fq.gz 189.1 MB
EGAF50000088230 fq.gz 196.1 MB
EGAF50000088231 fq.gz 257.2 MB
EGAF50000088232 fq.gz 264.6 MB
EGAF50000088233 fq.gz 41.4 MB
EGAF50000088234 fq.gz 43.2 MB
EGAF50000088235 fq.gz 266.2 MB
EGAF50000088236 fq.gz 274.2 MB
EGAF50000088237 fq.gz 57.1 MB
EGAF50000088238 fq.gz 58.9 MB
EGAF50000088239 fq.gz 252.2 MB
EGAF50000088240 fq.gz 267.7 MB
EGAF50000088241 fq.gz 200.9 MB
EGAF50000088242 fq.gz 206.8 MB
EGAF50000088243 fq.gz 123.6 MB
EGAF50000088244 fq.gz 133.8 MB
EGAF50000088245 fq.gz 117.7 MB
EGAF50000088246 fq.gz 120.5 MB
EGAF50000088247 fq.gz 192.1 MB
EGAF50000088248 fq.gz 107.5 MB
EGAF50000088249 fq.gz 122.2 MB
EGAF50000088250 fq.gz 125.0 MB
EGAF50000088251 fq.gz 128.9 MB
EGAF50000088252 fq.gz 33.1 MB
EGAF50000088253 fq.gz 34.6 MB
EGAF50000088254 fq.gz 232.7 MB
EGAF50000088255 fq.gz 235.2 MB
EGAF50000088256 fq.gz 76.3 MB
EGAF50000088257 fq.gz 77.5 MB
EGAF50000088258 fq.gz 92.3 MB
EGAF50000088259 fq.gz 94.1 MB
EGAF50000088260 fq.gz 333.0 MB
EGAF50000088261 fq.gz 339.3 MB
EGAF50000088262 fq.gz 106.6 MB
EGAF50000088263 fq.gz 114.1 MB
EGAF50000088264 fq.gz 393.4 MB
EGAF50000088265 fq.gz 400.2 MB
EGAF50000088266 fq.gz 259.0 MB
EGAF50000088267 fq.gz 306.8 MB
EGAF50000088268 fq.gz 311.3 MB
EGAF50000088269 fq.gz 607.2 MB
EGAF50000088270 fq.gz 525.7 kB
EGAF50000088271 fq.gz 447.3 MB
EGAF50000088272 fq.gz 463.1 MB
EGAF50000088273 fq.gz 333.1 MB
EGAF50000088274 fq.gz 339.7 MB
EGAF50000088275 fq.gz 261.0 MB
EGAF50000088276 fq.gz 265.1 MB
EGAF50000088277 fq.gz 68.4 MB
EGAF50000088278 fq.gz 69.8 MB
EGAF50000088279 fq.gz 195.9 MB
EGAF50000088280 fq.gz 52.7 MB
280 Files (52.8 GB)