Identification_and_functional_validation_of_driver_mutations_in_colorectal_cancer

Targeted exome sequencing of human colorectal cancers for the identification of novel cancer drivers.

1 Dataset

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Dataset ID	Description	Technology	Samples
EGAD00001004332	Familial adenomatous polyposis (FAP) and MUTYH‐associated polyposis (MAP) are inherited disorders associated with multiple colorectal adenomas that lead to a very high risk of colorectal cancer. The somatic mutations that drive adenoma development in these conditions have not been investigated comprehensively. In this study we performed analysis of paired colorectal adenoma and normal tissue DNA from individuals with FAP or MAP, sequencing 14 adenoma whole exomes (eight MAP, six FAP), 55 adenoma targeted exomes (33 MAP, 22 FAP) and germline DNA from each patient.	Illumina Genome Analyzer II Illumina HiSeq 2000	121