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ChIP-seq data of H3K4me3, H3K27ac and H3K27me3 on multiple human embryonic tissues.

The regulatory landscape of the human genome during organogenesis is undescribed for most tissues. We used ChIP-seq to survey histone modifications in 13 human embryonic tissues. We describe patterns of both common and tissue-specific marking of promoter activation and repression and use enhancer usage to infer regulatory pathways.

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID Description Technology Samples
EGAD00001004335 Illumina HiSeq 2500 Illumina HiSeq 4000 77
Publications Citations
Dynamic changes in the epigenomic landscape regulate human organogenesis and link to developmental disorders.
Nat Commun 11: 2020 3920
11
Expansion of ventral foregut is linked to changes in the enhancer landscape for organ-specific differentiation.
Nat Cell Biol 25: 2023 481-492
2