Alternative lengthening of telomeres in childhood neuroblastoma from genome to proteome

Study ID	Alternative Stable ID	Type
EGAS00001004349		Other

Study ID

Alternative Stable ID

Type

EGAS00001004349

Other

Study Description

Telomere maintenance by telomerase activation or alternative lengthening of telomeres (ALT) is a major determinant of poor outcome in neuroblastoma. Here, we screen for ALT in primary and relapsed neuroblastomas and characterize its features using multi-omics profiling. We aim to deepen the knowledge about the biology and clinical features of ALT-positive neuroblastomas by enriching ALT tumors in the study cohort independent of ATRX mutation status. Using a combination of genomic, transcriptomic and proteomic profiling, we provide evidence that this subgroup is clinically and molecularly distinct.

Dataset ID	Description	Technology	Samples
EGAD00001006587	94 sample with multi-omics analysis of ALT-positive neuroblastoma tumors, rna sequencing 94 sample with multi-omics analysis of ALT-positive neuroblastoma tumors, rna sequencing	HiSeq X Ten,Illumina HiSeq 2000,Illumina HiSeq 2500,Illumina HiSeq 4000	715
EGAD00001006625	144 sample from individuals with ALT-positive neuroblastoma tumors, chip-seq sequencing 144 sample from individuals with ALT-positive neuroblastoma tumors, chip-seq sequencing	Illumina HiSeq 2000,Illumina HiSeq 2500	144
EGAD00001006626	238 samples from individuals with ALT-positive neuroblastoma tumors, high coverage whole genome sequencing 238 samples from individuals with ALT-positive neuroblastoma tumors, high coverage whole genome sequencing	HiSeq X Ten,Illumina HiSeq 2000,Illumina HiSeq 2500	238
EGAD00001006637	89 samples of individuals with ALT-positive neuroblastoma tumors, exome sequencing 89 samples of individuals with ALT-positive neuroblastoma tumors, exome sequencing	Illumina HiSeq 2500,Illumina HiSeq 4000	89
EGAD00001006638	97 samples of individuals with ALT-positive neuroblastoma tumors, low coverage whole genome sequencing 97 samples of individuals with ALT-positive neuroblastoma tumors, low coverage whole genome sequencing	Illumina HiSeq 2500,Illumina HiSeq 4000	97
EGAD00001006639	63 samples of individuals with ALT-positive neuroblastoma tumors, high coverage whole genome sequencing 63 samples of individuals with ALT-positive neuroblastoma tumors, high coverage whole genome sequencing	HiSeq X Ten	63
EGAD00001006737	Proteome data of neuroblastoma patients Proteome data of neuroblastoma patients		34
EGAD00001006739	NA NA	HiSeq X Ten	17
EGAD00001006785	NA NA	Illumina HiSeq 4000	9

Dataset ID

Description

Technology

Samples

EGAD00001006587

94 sample with multi-omics analysis of ALT-positive neuroblastoma tumors, rna sequencing

HiSeq X Ten,Illumina HiSeq 2000,Illumina HiSeq 2500,Illumina HiSeq 4000

715

EGAD00001006625

144 sample from individuals with ALT-positive neuroblastoma tumors, chip-seq sequencing

Illumina HiSeq 2000,Illumina HiSeq 2500

144