Somatic inflammatory gene mutations accumulate in human ulcerative colitis epithelium

We performed whole exome sequencing and targeted sequencing of ulcerative colitis with/without colitis associated neoplasm and healthy indivisuals. The aim of this study was to calculate the influence of inflammation and age on a count of genetic mutations in colonic epithelium, and to identify the specific signal pathways on which the significant genetic mutations accumulating in ulcerative colitis patients' colonic epithelium.

• Type: Exome Sequencing
• Archiver: Japanese Genotype-phenotype Archive (JGA)